Linked Life Data

18297319

Source:http://linkedlifedata.com/resource/pubmed/id/18297319

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-1-16
pubmed:abstractText
Cyclic flexure of the coronary arteries can lead to spatially varying fluid and solid stress patterns. These patterns may explain the heterogenous distribution of atherosclerotic lesions. Here we describe the design and validation of an experimental system to simulate coronary-like flexure dynamics on intact arterial segments ex vivo. Our previously described ex vivo perfusion system was modified with a polymer flexure membrane controlled by a custom data acquisition/motion control system. The system was validated by perfusing arterial segments with pulsatile hemodynamics with or without cyclic flexure. Digital images were obtained to quantify dynamic vessel curvature and arc length. Tissue integrity was assessed by histology. The device generated physiologic curvatures (0-1.8 cm(-1)) at 1 Hz with a physiologic phase relationship with the pressure waveform. Additionally, the in vivo longitudinal extension ratio (40%) was maintained within 2.3% during the flexure cycle. Twelve hours of cyclic contact with the membrane did not compromise arterial segment integrity. This device provides a novel method to examine how the local biomechanical milieu could impact atherosclerotic lesion localization.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1617-7940
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
57-66
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Design and validation of a system to simulate coronary flexure dynamics on arterial segments perfused ex vivo.
pubmed:affiliation
Departments of Surgery and Bioengineering, The McGowan Institute for Regenerative Medicine, and the Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, PA, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural, Validation Studies