Linked Life Data

18295578

Source:http://linkedlifedata.com/resource/pubmed/id/18295578

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-2-25
pubmed:abstractText
Niches are local tissue microenvironments that maintain and regulate stem cells. Long-predicted from mammalian studies, these structures have recently been characterized within several invertebrate tissues using methods that reliably identify individual stem cells and their functional requirements. Although similar single-cell resolution has usually not been achieved in mammalian tissues, principles likely to govern the behavior of niches in diverse organisms are emerging. Considerable progress has been made in elucidating how the microenvironment promotes stem cell maintenance. Mechanisms of stem cell maintenance are key to the regulation of homeostasis and likely contribute to aging and tumorigenesis when altered during adulthood.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1097-4172
pubmed:author
pubmed:issnType
Electronic
pubmed:day
22
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
598-611
pubmed:dateRevised
2009-9-28
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life.
pubmed:affiliation
Howard Hughes Medical Institute, Life Sciences Institute, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI, 48109-2216, USA. seanjm@med.umich.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't