Linked Life Data

18294737

Source:http://linkedlifedata.com/resource/pubmed/id/18294737

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2008-10-20
pubmed:abstractText
Some heterocyclic systems namely stigmest-6-en-7, 5alpha thiourea and stigmest-6-en-7, 5alpha urea derivatives of steroids were synthesized by the reaction of stigmest-5-en-7 one with thiourea/urea in the presence of a few drops of conc. HCl at 80 degrees C in high yield. All the compounds have been characterized by means of elemental analyses, IR, 1H NMR, 13C NMR and mass spectroscopic data. The antibacterial activity was first tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) of compounds were determined. The results showed that steroidal thiourea derivatives inhibit growth as compared to steroidal urea derivatives of both type of the bacteria (Gram-positive and Gram-negative). Compounds 3 and 4 are better antibacterial agents as compared to standard drug chloramphenicol.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0223-5234
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2272-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Synthesis, characterization and in vitro antibacterial activity of thiourea and urea derivatives of steroids.
pubmed:affiliation
Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
pubmed:publicationType
Journal Article