Source:http://linkedlifedata.com/resource/pubmed/id/18294293
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2008-4-1
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pubmed:abstractText |
Hyperthermia has been used for many years to treat a variety of malignant tumors. The Curie temperature (Tc) is a transition point at which magnetic materials lose their magnetic properties, causing a cessation of current and thus heat production. The Tc enables automatic temperature control throughout a tumor as a result of the self-regulating nature of the thermosensitive material. We have developed a method of magnetically-induced hyperthermia using thermosensitive ferromagnetic particles (FMPs) with low Tc (43 degrees C), enough to mediate automatic temperature control. B16 melanoma cells were subcutaneously injected into the backs of C57BL/6 mice, after which tumors were allowed to grow to 5 mm in diameter. FMPs were then injected into the tumors, and the mice were divided into three groups: group I (no hyperthermia, control); group II (one hyperthermia treatment); and group III (hyperthermia twice a week for 4 weeks). When exposed to a magnetic field, the FMPs showed a sharp rise in heat production, reaching the Tc in tissue within 7 min, after which the tissue temperature stabilized at approximately the Tc. In groups I and II, all mice died within 30-45 days. In group III, however, 6 of 10 mice remained alive 120 days after beginning treatment. Our findings suggest that repeated treatment with magnetically-induced self-regulating hyperthermia, mediated by FMPs with a low Tc, is an effective means of suppressing melanoma growth. A key advantage of this hyperthermia system is that it is minimally invasive, requiring only a single injection for repeated treatments with automatic temperature control.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1349-7006
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
805-9
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pubmed:meshHeading |
pubmed-meshheading:18294293-Animals,
pubmed-meshheading:18294293-Disease Models, Animal,
pubmed-meshheading:18294293-Ferric Compounds,
pubmed-meshheading:18294293-Hyperthermia, Induced,
pubmed-meshheading:18294293-Magnetics,
pubmed-meshheading:18294293-Melanoma, Experimental,
pubmed-meshheading:18294293-Mice,
pubmed-meshheading:18294293-Mice, Inbred C57BL,
pubmed-meshheading:18294293-Skin Neoplasms,
pubmed-meshheading:18294293-Temperature
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pubmed:year |
2008
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pubmed:articleTitle |
Self-regulating hyperthermia induced using thermosensitive ferromagnetic material with a low Curie temperature.
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pubmed:affiliation |
Department of Surgery, Akita University, 1-1-1 Hondo, Akita City 010-8543, Japan. hsaito@doc.med.akita-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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