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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-3-20
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pubmed:abstractText |
The synthesis and trypanosomatic behavior of a new series of 1,4-bis(alkylamino)benzo[g]phthalazines 1- 4 containing the biologically significant imidazole ring are reported. In vitro antiparasitic activity against Trypanosoma cruzi epimastigotes is remarkable, especially for compound 2, whereas toxicity against Vero cells is very low. Conversion of epimastigotes to metacyclic forms in the presence of the tested compounds causes significant decreases in the amastigote and trypomastigote numbers. Fe-SOD inhibition is noteworthy, whereas effect on human Cu/Zn-SOD is negligible.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:Boutaleb-CharkiSamiraS,
pubmed-author:CampayoLucreciaL,
pubmed-author:CampuzanoJoseJ,
pubmed-author:CanoCarmenC,
pubmed-author:Gómez-ContrerasFernandoF,
pubmed-author:NavarroPilarP,
pubmed-author:OsunaAntonioA,
pubmed-author:PardoMercedesM,
pubmed-author:Sánchez-MorenoManuelM,
pubmed-author:SanzAna MAM,
pubmed-author:YuntaMaría J RMJ
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1962-6
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pubmed:meshHeading |
pubmed-meshheading:18293910-Animals,
pubmed-meshheading:18293910-Antiparasitic Agents,
pubmed-meshheading:18293910-Cercopithecus aethiops,
pubmed-meshheading:18293910-Humans,
pubmed-meshheading:18293910-Imidazoles,
pubmed-meshheading:18293910-Molecular Structure,
pubmed-meshheading:18293910-Parasitic Sensitivity Tests,
pubmed-meshheading:18293910-Phthalazines,
pubmed-meshheading:18293910-Stereoisomerism,
pubmed-meshheading:18293910-Structure-Activity Relationship,
pubmed-meshheading:18293910-Superoxide Dismutase,
pubmed-meshheading:18293910-Trypanosoma cruzi,
pubmed-meshheading:18293910-Vero Cells
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pubmed:year |
2008
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pubmed:articleTitle |
Efficient inhibition of iron superoxide dismutase and of Trypanosoma cruzi growth by benzo[g]phthalazine derivatives functionalized with one or two imidazole rings.
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pubmed:affiliation |
Departamento de Química Orgánica I, Facultad de Química, Universidad Complutense, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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