Linked Life Data

18293859

Source:http://linkedlifedata.com/resource/pubmed/id/18293859

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
136
pubmed:dateCreated
2008-2-25
pubmed:abstractText
The paper describes the location of TPH gene and the role of serotonin for a human organism. It analyses the path of serotonin formation from tryptophan as a result of hydroxylation and decarboxylation. It underscores the part the TPH gene plays in disclosing depressive disorders and suicidal tendencies. The opinions of different researchers on the relation between the individual TPH alleles and the occurrences of suicidal tendencies have been presented, indicating the obstacles in determining clear results of the research. The paper pays attention to the fact that variants of TPH may influence human behaviour. The author has also pointed to the role of hydroxyindole acetic acid in cerebrospinal fluid, which may be significant in suicidal tendencies. Pathogenesis of periodical depressive mood disorders has also been emphasized. A location of serotonin transporter gene and a role of its polymorphism in arising depressive disorders have been presented. Genetically conditioned differences in effectiveness of the therapy in patients with recognised diagnosis of depressive syndrome indicate strong relations with pharmacokinetic and pharmacodynamic mechanism of antidepressant activities.
pubmed:language
pol
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1426-9686
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
315-6
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
[Association between the TPH2 gene and suicidal behavior].
pubmed:affiliation
Uniwersytet Medyczny w ?odzi, Klinika Psychiatrii Doroslych. ann.kamrowska@poczta.onet.pl
pubmed:publicationType
Journal Article, English Abstract