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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-4-1
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pubmed:abstractText |
Mutations in the gene autoimmune regulator (AIRE) cause autoimmune polyendocrinopathy candidiasis ectodermal dystrophy. AIRE is expressed in thymic medullary epithelial cells, where it promotes the expression of tissue-restricted antigens. By the combined use of biochemical and biophysical methods, we show that AIRE selectively interacts with histone H3 through its first plant homeodomain (PHD) finger (AIRE-PHD1) and preferentially binds to non-methylated H3K4 (H3K4me0). Accordingly, in vivo AIRE binds to and activates promoters containing low levels of H3K4me3 in human embryonic kidney 293 cells. We conclude that AIRE-PHD1 is an important member of a newly identified class of PHD fingers that specifically recognize H3K4me0, thus providing a new link between the status of histone modifications and the regulation of tissue-restricted antigen expression in thymus.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-10634424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-10677297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-11230159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-12376594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-12612579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-15964547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-15983066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-16126959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-16297627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-16551260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-16728974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-16728976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-16728977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-16728978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-17320160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-17513766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-17641664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-17687327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-17687328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-18033247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-7701562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18292755-9398839
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1469-221X
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pubmed:author |
pubmed-author:BottomleyMatthew JMJ,
pubmed-author:ChignolaFrancescaF,
pubmed-author:GaetaniMassimilianoM,
pubmed-author:HetényiCsabaC,
pubmed-author:LiivIngridI,
pubmed-author:MaranUkoU,
pubmed-author:MollicaLucaL,
pubmed-author:MuscoGiovannaG,
pubmed-author:OrgTõnisT,
pubmed-author:PetersonPärtP,
pubmed-author:RebaneAnaA
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
370-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18292755-Calorimetry,
pubmed-meshheading:18292755-Cell Line,
pubmed-meshheading:18292755-Chromatin Immunoprecipitation,
pubmed-meshheading:18292755-Gene Expression Regulation,
pubmed-meshheading:18292755-Histones,
pubmed-meshheading:18292755-Humans,
pubmed-meshheading:18292755-Models, Molecular,
pubmed-meshheading:18292755-Polyendocrinopathies, Autoimmune,
pubmed-meshheading:18292755-Protein Structure, Tertiary,
pubmed-meshheading:18292755-Transcription Factors
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pubmed:year |
2008
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pubmed:articleTitle |
The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression.
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pubmed:affiliation |
Molecular Pathology, University of Tartu, Tartu 50411, Estonia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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