Linked Life Data

18292360

Source:http://linkedlifedata.com/resource/pubmed/id/18292360

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-2-22
pubmed:abstractText
Research into the molecular and cellular pathways focusing on bone fragility and fracture-healing has led to new potential treatments to aid in fracture-healing. This research has focused on physical as well as biological modes of treatment. As new products and methods are derived, it is essential to develop effective and sensitive noninvasive means by which early changes in the fracture repair process can be detected. Specialized noninvasive and/or nondestructive techniques can provide structural information about local and systemic skeletal health, the propensity to fracture, and the pathophysiology of bone fragility. The methods available to quantitatively assess macrostructure include computed tomography and, particularly, volumetric quantitative computed tomography. Methods for assessing microstructure of trabecular bone include high-resolution computed tomography, microquantitative computed tomography, high-resolution magnetic resonance imaging, and micromagnetic resonance imaging. These new techniques help to illustrate the process of fracture-healing by defining the skeletal response to innovative therapies and assessing biomechanical relationships. This review presents perspectives on the advanced imaging modalities that are currently available and on recent developments that may improve the detection and understanding of bone fragility and fracture-healing.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1535-1386
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
90 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
68-78
pubmed:dateRevised
2010-10-25
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Advanced imaging of bone macrostructure and microstructure in bone fragility and fracture repair.
pubmed:affiliation
Department of Radiology, University of California at San Francisco, 550 Parnassus Avenue, San Francisco, CA 94143, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't