rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-3-17
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pubmed:abstractText |
A novel class of azetidinone acid-derived dual PPARalpha/gamma agonists has been synthesized for the treatment of diabetes and dyslipidemia. The preferred stereochemistry in this series for binding and functional agonist activity against both PPARalpha and PPARgamma receptors was shown to be 3S,4S. Synthesis, in vitro and in vivo activities of compounds in this series are described. A high-yielding method for N-arylation of azetidinone esters is also described.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:CapMichaelM,
pubmed-author:ChangChiehyingC,
pubmed-author:ChengPeter T WPT,
pubmed-author:ChuCuixiaC,
pubmed-author:DevasthalePratikP,
pubmed-author:DoweykoArthur MAM,
pubmed-author:FarrellyDennisD,
pubmed-author:GuLiqunL,
pubmed-author:HariharanNarayananN,
pubmed-author:HarrityThomasT,
pubmed-author:HosagraharaVinayakV,
pubmed-author:KadiyalaPathanjaliP,
pubmed-author:KunselmanLoriL,
pubmed-author:LippyJonathanJ,
pubmed-author:LockeKennethK,
pubmed-author:MorganNathanN,
pubmed-author:MuckelbauerJodiJ,
pubmed-author:O'MalleyKevinK,
pubmed-author:PonticielloRandyR,
pubmed-author:RyonoDenisD,
pubmed-author:VighB JBJ,
pubmed-author:ZahlerRobertR,
pubmed-author:ZeboRachelR,
pubmed-author:ZhangLisaL,
pubmed-author:ZhangLitaoL
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pubmed:issnType |
Electronic
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pubmed:day |
15
|
pubmed:volume |
18
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1939-44
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pubmed:dateRevised |
2008-10-28
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pubmed:meshHeading |
pubmed-meshheading:18291645-Administration, Oral,
pubmed-meshheading:18291645-Animals,
pubmed-meshheading:18291645-Azetidines,
pubmed-meshheading:18291645-Biological Availability,
pubmed-meshheading:18291645-Copper,
pubmed-meshheading:18291645-Crystallography, X-Ray,
pubmed-meshheading:18291645-Cytochrome P-450 Enzyme System,
pubmed-meshheading:18291645-Diabetes Mellitus, Experimental,
pubmed-meshheading:18291645-Dyslipidemias,
pubmed-meshheading:18291645-Ether-A-Go-Go Potassium Channels,
pubmed-meshheading:18291645-Glucose,
pubmed-meshheading:18291645-Mice,
pubmed-meshheading:18291645-Mice, Mutant Strains,
pubmed-meshheading:18291645-Molecular Structure,
pubmed-meshheading:18291645-PPAR alpha,
pubmed-meshheading:18291645-PPAR gamma,
pubmed-meshheading:18291645-Protein Conformation,
pubmed-meshheading:18291645-Stereoisomerism,
pubmed-meshheading:18291645-Structure-Activity Relationship,
pubmed-meshheading:18291645-Triglycerides
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pubmed:year |
2008
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pubmed:articleTitle |
Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.
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pubmed:affiliation |
Metabolic Diseases Chemistry, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-5400, USA.
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pubmed:publicationType |
Journal Article
|