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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-8-1
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pubmed:abstractText |
Polymerase chain reaction (PCR) identified regions of the gag, LTR, and env genes of human immunodeficiency virus type 1 (HIV-1) in 5 (13%) of 38 high-risk homosexual men who were negative for HIV-1 antibodies by Western blot (WB). Significant increases in CD8+ cells, particularly those bearing activation CD8+CD38+ and CD8+Ia+ antigens, and marked reductions in CD4+ cells were detected in WB-PCR+ subjects compared with 33 WB-PCR- homosexuals. WB-PCR+ subjects had impaired B cell but not T cell functions. Immunologic characteristics of WB-PCR+ homosexuals were indistinguishable from those of 17 WB+PCR+ subjects. Subjects progressing from WB-PCR- to WB-PCR+ to WB+PCR+ showed sequential phenotypic and functional alterations in their B and T cell compartments. These changes and the presence of HIV-1 genomic sequences were the first indications of HIV-1 infection and together with p24 antigenemia signified an inevitable progression to AIDS.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1899
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
183-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1829106-Adult,
pubmed-meshheading:1829106-B-Lymphocytes,
pubmed-meshheading:1829106-DNA, Viral,
pubmed-meshheading:1829106-Gene Products, gag,
pubmed-meshheading:1829106-Genes, env,
pubmed-meshheading:1829106-Genes, gag,
pubmed-meshheading:1829106-HIV Antibodies,
pubmed-meshheading:1829106-HIV Antigens,
pubmed-meshheading:1829106-HIV Core Protein p24,
pubmed-meshheading:1829106-HIV Infections,
pubmed-meshheading:1829106-HIV-1,
pubmed-meshheading:1829106-Homosexuality,
pubmed-meshheading:1829106-Humans,
pubmed-meshheading:1829106-Leukocyte Count,
pubmed-meshheading:1829106-Longitudinal Studies,
pubmed-meshheading:1829106-Male,
pubmed-meshheading:1829106-Polymerase Chain Reaction,
pubmed-meshheading:1829106-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:1829106-T-Lymphocytes,
pubmed-meshheading:1829106-T-Lymphocytes, Regulatory,
pubmed-meshheading:1829106-Viral Core Proteins
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pubmed:year |
1991
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pubmed:articleTitle |
Human immunodeficiency virus type 1 (HIV-1) genomic sequences and distinct changes in CD8+ lymphocytes precede detectable levels of HIV-1 antibodies in high-risk homosexuals.
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pubmed:affiliation |
Department of Neoplastic Diseases, Mount Sinai School of Medicine, New York, New York 10029.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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