Source:http://linkedlifedata.com/resource/pubmed/id/18290860
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2008-2-22
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| pubmed:abstractText |
Paraoxonase 1 (PON1) is an antioxidant high-density lipoprotein-bound enzyme, which was recently found to be expressed in the islets of Langerhans. A substitution (Q/R) at position 192 results in enzymes with different activity. Oxidation has been implicated in the onset of diabetes, and it can be hypothesized that PON1 may have a protective effect on diabetes. Our aim was to compare PON1 activities and PON1 Q/R phenotypes in subjects with different degrees of glucose intolerance.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
|
| pubmed:issn |
1464-5491
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
25
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
186-93
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| pubmed:meshHeading |
pubmed-meshheading:18290860-Aryldialkylphosphatase,
pubmed-meshheading:18290860-Diabetes Mellitus, Type 2,
pubmed-meshheading:18290860-Diagnosis, Differential,
pubmed-meshheading:18290860-Female,
pubmed-meshheading:18290860-Glucose Intolerance,
pubmed-meshheading:18290860-Humans,
pubmed-meshheading:18290860-Lipoproteins, LDL,
pubmed-meshheading:18290860-Male,
pubmed-meshheading:18290860-Middle Aged,
pubmed-meshheading:18290860-Phenotype
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| pubmed:year |
2008
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| pubmed:articleTitle |
Paraoxonase 1 phenotype distribution and activity differs in subjects with newly diagnosed Type 2 diabetes (the CODAM Study).
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| pubmed:affiliation |
Centre for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, The Netherlands. saskia.van.den.berg@rivm.nl
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| pubmed:publicationType |
Journal Article
|