Source:http://linkedlifedata.com/resource/pubmed/id/18290631
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2008-4-28
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pubmed:abstractText |
Four new purine alkaloids, namely, 6-(1'-purine-6',8'-dionyl)suberosanone ( 1), 3,9-(2-imino-1-methyl-4-imidazolidinone-5-yl)isopropenylpurine-6,8-dione ( 2), 1-(3'-carbonylbutyl)purine-6,8-dione ( 3), and 9-(3'-carbonylbutyl)purine-6,8-dione ( 4), together with three known compounds, guanosine ( 5), thymidine ( 6), and adenosine ( 7), were isolated from the EtOH/CH 2Cl 2 extracts of the South China Sea gorgonian Subergorgia suberosa. The structures of 1- 4 were determined on the basis of extensive spectroscopic analysis, including 1D and 2D NMR data. Compounds 1- 4 all showed weak cytotoxicity toward human cancer cell lines MDA-MB-231 and A435.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0163-3864
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
716-8
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pubmed:meshHeading |
pubmed-meshheading:18290631-Alkaloids,
pubmed-meshheading:18290631-Animals,
pubmed-meshheading:18290631-Anthozoa,
pubmed-meshheading:18290631-Antineoplastic Agents,
pubmed-meshheading:18290631-Drug Screening Assays, Antitumor,
pubmed-meshheading:18290631-Humans,
pubmed-meshheading:18290631-Molecular Structure,
pubmed-meshheading:18290631-Purines
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pubmed:year |
2008
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pubmed:articleTitle |
Purine alkaloids from the South China Sea gorgonian Subergorgia suberosa.
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pubmed:affiliation |
Key Laboratory of Marine Bio-resourses Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, The Chinese Academy of Sciences, Guangdong, People's Republic of China. shuhuaqi2001@yahoo.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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