Linked Life Data

18289231

Source:http://linkedlifedata.com/resource/pubmed/id/18289231

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-2-21
pubmed:abstractText
Hypoxaemia during anaesthetic induction in obstetrics is hazardous for mother and baby, but the onset of desaturation can be delayed by pre-oxygenation. This study investigated pre-oxygenation during pregnancy using computer simulation. The Nottingham Physiology Simulator was configured to replicate normal pregnant physiology. Three pregnant and three non-pregnant subjects were created, representing population variation according to published physiological values. They underwent pre-oxygenation by tidal and vital capacity breathing of 100% oxygen. Pre-oxygenation during tidal breathing proceeded more rapidly in pregnancy, the median [range] time to achieve 95% of the maximum change in P(E)O2 being 1 min 37 s [1:23-1:52] in pregnant subjects, compared to 2 min 51 s [2:28-3:15] in non-pregnant subjects. Vital capacity pre-oxygenation required seven breaths [5-10] in pregnant subjects, compared to six breaths [4-9] in non-pregnant subjects, to achieve the same P(E)O2 as after 95% complete tidal pre-oxygenation. We recommend 2 min of tidal breathing for pre-oxygenation in pregnancy.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1365-2044
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
259-63
pubmed:dateRevised
2008-4-4
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Pre-oxygenation in pregnancy: an investigation using physiological modelling.
pubmed:affiliation
Queen's Medical Centre campus, Nottingham University Hospitals NHS Trust, Derby Road, Nottingham NG7 2UH, UK.
pubmed:publicationType
Journal Article