| pubmed-article:18288637 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18288637 | lifeskim:mentions | umls-concept:C1167250 | lld:lifeskim |
| pubmed-article:18288637 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:18288637 | lifeskim:mentions | umls-concept:C0230653 | lld:lifeskim |
| pubmed-article:18288637 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:18288637 | lifeskim:mentions | umls-concept:C0079284 | lld:lifeskim |
| pubmed-article:18288637 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:18288637 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:18288637 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:18288637 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:18288637 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:18288637 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:18288637 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:18288637 | lifeskim:mentions | umls-concept:C0205266 | lld:lifeskim |
| pubmed-article:18288637 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18288637 | pubmed:dateCreated | 2008-5-29 | lld:pubmed |
| pubmed-article:18288637 | pubmed:abstractText | We have investigated the role of NAADP-mediated Ca(2+) mobilization in endothelin (ET) signaling via endothelin receptor subtype A (ETA) and endothelin receptor subtype B (ETB) in rat peritubular smooth muscle cells. Microinjection and extracellular application of NAADP were both able to elicit Ca(2+) release which was blocked by inhibitory concentrations of NAADP, by impairing Ca(2+) uptake in acidic stores with bafilomycin, and by thapsigargin. Ca(2+) release in response to selective ETB stimulation was abolished by inhibition of NAADP signaling through the same strategies, while these treatments only partially impaired ETA-dependent Ca(2+) signaling, showing that transduction of the ETB signal is dependent on NAADP. In addition, we show that lipid rafts/caveolae contain ETA, ETB, and NAADP/cADPR generating enzyme CD38 and that stimulation of ETB receptors results in increased CD38 activity; interestingly, ETB- (but not ETA-) mediated Ca(2+) responses were antagonized by disruption of lipid rafts/caveolae with methyl-beta-cyclodextrin. These data demonstrate a primary role of NAADP in ETB-mediated Ca(2+) signaling and strongly suggest a novel role of lipid rafts/caveolae in triggering ET-induced NAADP signaling. | lld:pubmed |
| pubmed-article:18288637 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18288637 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288637 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18288637 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18288637 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18288637 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18288637 | pubmed:issn | 1097-4652 | lld:pubmed |
| pubmed-article:18288637 | pubmed:author | pubmed-author:GenazzaniArma... | lld:pubmed |
| pubmed-article:18288637 | pubmed:author | pubmed-author:BillingtonRic... | lld:pubmed |
| pubmed-article:18288637 | pubmed:author | pubmed-author:PalombiFioret... | lld:pubmed |
| pubmed-article:18288637 | pubmed:author | pubmed-author:ZiparoElioE | lld:pubmed |
| pubmed-article:18288637 | pubmed:author | pubmed-author:FilippiniAnto... | lld:pubmed |
| pubmed-article:18288637 | pubmed:author | pubmed-author:DebiddaMarcel... | lld:pubmed |
| pubmed-article:18288637 | pubmed:author | pubmed-author:D'AlessioAles... | lld:pubmed |
| pubmed-article:18288637 | pubmed:author | pubmed-author:GambaraGuidoG | lld:pubmed |
| pubmed-article:18288637 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18288637 | pubmed:volume | 216 | lld:pubmed |
| pubmed-article:18288637 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18288637 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18288637 | pubmed:pagination | 396-404 | lld:pubmed |
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| pubmed-article:18288637 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18288637 | pubmed:articleTitle | NAADP-induced Ca(2+ signaling in response to endothelin is via the receptor subtype B and requires the integrity of lipid rafts/caveolae. | lld:pubmed |
| pubmed-article:18288637 | pubmed:affiliation | Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Histology and Medical Embryology, University of Rome La Sapienza, Rome, Italy. | lld:pubmed |
| pubmed-article:18288637 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18288637 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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