Source:http://linkedlifedata.com/resource/pubmed/id/18287936
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2008-2-21
|
| pubmed:abstractText |
A variation in catechol-O-methyltransferase (COMT) gene (Val(108/158)Met) affects the physiological response of hippocampal-prefrontal circuits, predicts variation in human memory and is associated with increased risk for psychiatric disorders. Using optimized voxel-based morphometry we studied the effect of this functional polymorphism on the anatomy of the hippocampus, and the prefrontal cortex. Fifty-seven healthy participants were investigated (nine had Met/Met, 30 Val/Met, and 14 Val/Val). Voxel-based morphometry showed that individuals who are homozygous for the Val-COMT allele had greater gray matter volume of the prefrontal cortex bilaterally, whereas Met-COMT carriers were associated with increased tissue volume of the hippocampus bilaterally. This study provides evidence that the Val(108/158)Met polymorphism of the COMT gene might be responsible for individual variation in the human brain morphology.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0959-4965
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
5
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
405-8
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:18287936-Adult,
pubmed-meshheading:18287936-Amino Acid Substitution,
pubmed-meshheading:18287936-Brain Mapping,
pubmed-meshheading:18287936-Catechol O-Methyltransferase,
pubmed-meshheading:18287936-DNA Mutational Analysis,
pubmed-meshheading:18287936-Dopamine,
pubmed-meshheading:18287936-Female,
pubmed-meshheading:18287936-Functional Laterality,
pubmed-meshheading:18287936-Gene Frequency,
pubmed-meshheading:18287936-Genetic Testing,
pubmed-meshheading:18287936-Genotype,
pubmed-meshheading:18287936-Hippocampus,
pubmed-meshheading:18287936-Homozygote,
pubmed-meshheading:18287936-Humans,
pubmed-meshheading:18287936-Image Processing, Computer-Assisted,
pubmed-meshheading:18287936-Magnetic Resonance Imaging,
pubmed-meshheading:18287936-Male,
pubmed-meshheading:18287936-Methionine,
pubmed-meshheading:18287936-Middle Aged,
pubmed-meshheading:18287936-Polymorphism, Genetic,
pubmed-meshheading:18287936-Prefrontal Cortex,
pubmed-meshheading:18287936-Valine
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Impact of catechol-O-methyltransferase Val(108/158) Met genotype on hippocampal and prefrontal gray matter volume.
|
| pubmed:affiliation |
Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone 87050, Cosenza, Italy. a.cerasa@isn.cnr.it
|
| pubmed:publicationType |
Journal Article
|