|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0019878,
umls-concept:C0022661,
umls-concept:C0023516,
umls-concept:C0030705,
umls-concept:C0032105,
umls-concept:C0232804,
umls-concept:C0376452,
umls-concept:C0403447,
umls-concept:C0741968,
umls-concept:C1280412,
umls-concept:C1306673,
umls-concept:C2348867
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|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2008-7-29
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|
pubmed:abstractText |
Patients with chronic kidney disease (CKD) have an increased risk of cardiovascular disease (CVD). Preliminary evidence suggests a role for global DNA hypomethylation in the pathogenesis of atherosclerotic complications in CKD. The aims of this study in patients with stage 2-4 CKD were (1) to assess the association between renal function and DNA methylation, (2) to assess the association between DNA methylation and two markers of atherosclerosis [common carotid intima-media thickness (CCA-IMT)] and brachial artery endothelium-dependent, flow-mediated dilatation (BA-FMD) and (3) to examine the effect of a multi-step treatment strategy on DNA methylation.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1460-2385
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
23
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2586-92
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pubmed:meshHeading |
pubmed-meshheading:18287179-Adult,
pubmed-meshheading:18287179-Carotid Arteries,
pubmed-meshheading:18287179-DNA Methylation,
pubmed-meshheading:18287179-Double-Blind Method,
pubmed-meshheading:18287179-Female,
pubmed-meshheading:18287179-Glomerular Filtration Rate,
pubmed-meshheading:18287179-Homocysteine,
pubmed-meshheading:18287179-Humans,
pubmed-meshheading:18287179-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:18287179-Kidney Failure, Chronic,
pubmed-meshheading:18287179-Leukocytes,
pubmed-meshheading:18287179-Male,
pubmed-meshheading:18287179-Middle Aged,
pubmed-meshheading:18287179-Pravastatin,
pubmed-meshheading:18287179-Tunica Intima,
pubmed-meshheading:18287179-Vitamin B Complex,
pubmed-meshheading:18287179-Vitamin E
|
|
pubmed:year |
2008
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|
pubmed:articleTitle |
Association between global leukocyte DNA methylation, renal function, carotid intima-media thickness and plasma homocysteine in patients with stage 2-4 chronic kidney disease.
|
|
pubmed:affiliation |
Department of Internal Medicine, Institute for Cardiovascular Research, VU University Medical Center, VU University, Amsterdam, The Netherlands. p.nanayakkara@vumc.nl
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|
pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
