Linked Life Data

1828545

Source:http://linkedlifedata.com/resource/pubmed/id/1828545

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-7-17
pubmed:abstractText
The role of endogenous excitatory amino acid neurotransmission in the regulation of progesterone and triamcinolone acetonide-induced LH and FSH release was examined. Estrogen-primed ovariectomized rats were utilized in this study. Progesterone or triamcinolone acetonide (1 mg/kg body weight) treatment led to a highly significant elevation of serum LH and FSH levels 5 h later. Treatment with the selective noncompetitive NMDA receptor antagonist, MK801, had no effect on serum LH and FSH levels when compared to estrogen controls. However, MK801 administered 1 h prior to progesterone or triamcinolone acetonide administration completely blocked their ability to induce LH and FSH surges. These studies demonstrate for the first time the involvement of endogenous excitatory amino acid neurotransmission in the mediation of progesterone and corticosteroid-induced LH and FSH surges.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-10
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Endogenous excitatory amino acid regulation of the progesterone-induced LH and FSH surge in estrogen-primed ovariectomized rats.
pubmed:affiliation
Department of Physiology and Endocrinology, Medical College of Georgia, Augusta.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.