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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-7-30
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pubmed:abstractText |
Oral submucous fibrosis (OSF) is a high-risk pre-cancerous condition where 7-13% of these patients develop head and neck squamous cell carcinoma (HNSCC). To date there is no cancer predictive markers for OSF patients. Genomic instability hallmarks early genetic events during malignant transformation causing loss of heterozygosity (LOH) and chromosomal copy number abnormality. However, to date there is no study on genomic instability in OSF. Although this condition is known as a high-risk pre-cancerous condition, there is no data regarding the genomic status of this disease in terms of genetic susceptibility to malignant transformation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1600-0714
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pubmed:author |
pubmed-author:AriyawardanaAA,
pubmed-author:ChaplinTT,
pubmed-author:CruchleyAA,
pubmed-author:FortuneFF,
pubmed-author:Hagi-PavliEE,
pubmed-author:LalliAA,
pubmed-author:PitiyageGG,
pubmed-author:StewartJ EJE,
pubmed-author:TanM JMJ,
pubmed-author:TilakaratneW MWM,
pubmed-author:WaseemAA,
pubmed-author:YoungB DBD
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pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
430-6
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pubmed:meshHeading |
pubmed-meshheading:18284545-Adult,
pubmed-meshheading:18284545-Aged,
pubmed-meshheading:18284545-Carcinoma, Squamous Cell,
pubmed-meshheading:18284545-Cell Transformation, Neoplastic,
pubmed-meshheading:18284545-DNA Fingerprinting,
pubmed-meshheading:18284545-Female,
pubmed-meshheading:18284545-Genetic Markers,
pubmed-meshheading:18284545-Head and Neck Neoplasms,
pubmed-meshheading:18284545-Humans,
pubmed-meshheading:18284545-Loss of Heterozygosity,
pubmed-meshheading:18284545-Male,
pubmed-meshheading:18284545-Microarray Analysis,
pubmed-meshheading:18284545-Middle Aged,
pubmed-meshheading:18284545-Oral Submucous Fibrosis,
pubmed-meshheading:18284545-Polymorphism, Single Nucleotide,
pubmed-meshheading:18284545-Precancerous Conditions
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pubmed:year |
2008
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pubmed:articleTitle |
Fingerprinting genomic instability in oral submucous fibrosis.
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pubmed:affiliation |
Centre for Clinical and Diagnostic Oral Sciences, Barts and The London School of Medicine and Dentistry, Institute of Cell and Molecular Sciences Building, Queen Mary, University of London, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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