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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-3-19
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pubmed:abstractText |
Growth arrest-specific gene 6 (Gas6), identified in 1995, acts as the ligand to the Axl/Tyro3 family of tyrosine kinase receptors and exerts mitogenic activity when bound to these receptors. Overexpression of the Axl/Tyro3 receptor family has been found in breast, ovarian and lung tumours. Gas6 is upregulated 23-fold by progesterone acting through the progesterone receptor B (PRB). Recently, Gas6 has been shown to be a target for overexpression and amplification in breast cancer. Quantitative real-time PCR analysis was used to determine the levels of Gas6 mRNA expression in 49 primary breast carcinomas. Expression of PRB protein was evaluated immunohistochemically with a commercially available PRB antibody. The results showed a positive association between PRB protein and Gas6 mRNA levels (P=0.04). Gas6 correlated positively with a number of favourable prognostic variables including lymph node negativity (P=0.0002), younger age at diagnosis (P=0.04), smaller size of tumours (P=0.02), low Nottingham prognostic index scores (P=0.03) and low nuclear morphology (P=0.03). This study verifies for the first time the association between PRB and Gas6 in breast cancer tissue.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-11154277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-11175853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-11250680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-11484958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-11717311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-12796028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-15452374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-15605394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-15650770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-15733062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-15790929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-16109739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-16354588,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-7854420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-8336730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-8528051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-8595896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-8637702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-9160883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18283315-9395235
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0007-0920
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pubmed:author |
pubmed-author:ChungW YWY,
pubmed-author:CookeFF,
pubmed-author:DervanP APA,
pubmed-author:FitzpatrickPP,
pubmed-author:FlynnBB,
pubmed-author:FoxEE,
pubmed-author:GallagherEE,
pubmed-author:GoldrickA McAM,
pubmed-author:HarrisonMM,
pubmed-author:KerinM JMJ,
pubmed-author:Mc CannAA,
pubmed-author:Mc CormackOO
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1141-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18283315-Adult,
pubmed-meshheading:18283315-Aged,
pubmed-meshheading:18283315-Aged, 80 and over,
pubmed-meshheading:18283315-Breast Neoplasms,
pubmed-meshheading:18283315-Disease-Free Survival,
pubmed-meshheading:18283315-Female,
pubmed-meshheading:18283315-Gene Expression,
pubmed-meshheading:18283315-Humans,
pubmed-meshheading:18283315-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:18283315-Middle Aged,
pubmed-meshheading:18283315-Polymerase Chain Reaction,
pubmed-meshheading:18283315-RNA, Messenger,
pubmed-meshheading:18283315-Receptors, Progesterone,
pubmed-meshheading:18283315-Risk Factors,
pubmed-meshheading:18283315-Survival Analysis
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pubmed:year |
2008
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pubmed:articleTitle |
Growth arrest-specific gene 6 expression in human breast cancer.
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pubmed:affiliation |
UCD School of Medicine and Medical Science, UCD Conway Institute, Belfield, Dublin 4, Ireland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Validation Studies
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