|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2008-2-18
|
|
pubmed:abstractText |
A phase I trial of the antiangiogenesis agent cilengitide (EMD 121974), an alpha v beta 3,5 integrin antagonist, was performed to estimate the maximum-tolerated dose (MTD) and describe dose-limiting toxicities (DLTs) and the incidence and severity of other toxicities when administered to children with refractory brain tumors.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1527-7755
|
|
pubmed:author |
pubmed-author:BoyettJames MJM,
pubmed-author:EllenbogenRichard GRG,
pubmed-author:GoldmanStewartS,
pubmed-author:KieranMark WMW,
pubmed-author:KocakMehmetM,
pubmed-author:KunLarry ELE,
pubmed-author:LafondDeborahD,
pubmed-author:MacDonaldTobey JTJ,
pubmed-author:PhillipsPeterP,
pubmed-author:PoussaintTina YoungTY,
pubmed-author:StewartClinton FCF
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
20
|
|
pubmed:volume |
26
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
919-24
|
|
pubmed:meshHeading |
pubmed-meshheading:18281665-Adolescent,
pubmed-meshheading:18281665-Adult,
pubmed-meshheading:18281665-Angiogenesis Inhibitors,
pubmed-meshheading:18281665-Brain Neoplasms,
pubmed-meshheading:18281665-Child,
pubmed-meshheading:18281665-Child, Preschool,
pubmed-meshheading:18281665-Drug Administration Schedule,
pubmed-meshheading:18281665-Female,
pubmed-meshheading:18281665-Genotype,
pubmed-meshheading:18281665-Humans,
pubmed-meshheading:18281665-Infant,
pubmed-meshheading:18281665-Infusions, Intravenous,
pubmed-meshheading:18281665-Magnetic Resonance Imaging,
pubmed-meshheading:18281665-Male,
pubmed-meshheading:18281665-P-Glycoprotein,
pubmed-meshheading:18281665-Snake Venoms,
pubmed-meshheading:18281665-Treatment Outcome
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012.
|
|
pubmed:affiliation |
Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010, USA. tmacdona@cnmc.org
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I,
Research Support, N.I.H., Extramural
|
