Linked Life Data

18280798

Source:http://linkedlifedata.com/resource/pubmed/id/18280798

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-3-10
pubmed:abstractText
We review the evidence that the function of the SLC25A19 gene product, previously identified as the mitochondrial deoxyribonucleotide carrier (DNC), is actually the transport of thiamine pyrophosphate. This evidence comes from enzyme kinetics, homologous yeast protein alignments, gene knockout studies, and clinical samples from Amish Microcephaly patients. This diverse body of evidence consistently points to the conclusion that SLC25A19 is not the true mitochondrial DNC gene. The identification of the correct mitochondrial DNC is important for research on the genetic diseases of mitochondrial DNA maintenance and the toxicity experienced by many HIV patients undergoing antiretroviral therapy involving nucleoside analogs.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1567-7249
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-8
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The evidence that the DNC (SLC25A19) is not the mitochondrial deoxyribonucleotide carrier.
pubmed:affiliation
Virginia Bioinformatics Institute, Virginia Polytechnic and State University, Washington Street, MC 0477, Blacksburg, VA 24061, USA.
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural