Linked Life Data

18280773

Source:http://linkedlifedata.com/resource/pubmed/id/18280773

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2008-9-22
pubmed:abstractText
Hereditary retinoblastoma patients are at an increased risk for subsequent primary tumors after successful treatment for their initial cancer. Two mechanisms may be responsible for this increased incidence of second malignancies: genetic susceptibility (RB1 gene alterations) and induction by radiation that is frequently used as treatment for retinoblastoma. Because of the high cure rates obtained in the treatment of retinoblastoma, the risk of subsequent primary tumors is substantial, especially in the radiation field. We present four retinoblastoma survivors who developed multiple subsequent primary tumors. Two retinoblastoma survivors developed one and the other two patients two subsequent primary tumors. Despite extensive treatments two patients died of their second primary tumor in the head and neck region. The head and neck surgeon has an increasingly important role in the diagnosis and management of subsequent primary tumors in retinoblastoma survivors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1368-8375
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
982-5
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Subsequent tumors in retinoblastoma survivors: the role of the head and neck surgeon.
pubmed:affiliation
Department of Otolaryngology/Head and Neck Surgery, Vrije Universiteit Medical Center, P.O. Box 7057, De Boelelaan 1117, 1081 Amsterdam, The Netherlands. r.bree@vumc.nl
pubmed:publicationType
Journal Article, Case Reports