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rdf:type |
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lifeskim:mentions |
umls-concept:C0003451,
umls-concept:C0007613,
umls-concept:C0021311,
umls-concept:C0039194,
umls-concept:C0042749,
umls-concept:C0087111,
umls-concept:C0220847,
umls-concept:C0332206,
umls-concept:C0441889,
umls-concept:C1280500,
umls-concept:C1540292
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pubmed:issue |
4
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pubmed:dateCreated |
2008-3-7
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|
pubmed:abstractText |
HCV-specific T cells in acute hepatitis C with subsequent chronic evolution are dysfunctional and most of them express PD-1. The aim of the study was to investigate to what extent the antiviral T cell function can be restored by reversing T cell exhaustion by PD-1/PD-L1 blockade and to assess whether this restoration is favored by IFN-alpha treatment.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
|
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD274,
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CD274 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis C Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/PDCD1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Receptor,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0168-8278
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
548-58
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18280607-Antigens, CD,
pubmed-meshheading:18280607-Antigens, CD274,
pubmed-meshheading:18280607-Antiviral Agents,
pubmed-meshheading:18280607-Apoptosis Regulatory Proteins,
pubmed-meshheading:18280607-Cell Proliferation,
pubmed-meshheading:18280607-Dendritic Cells,
pubmed-meshheading:18280607-Flow Cytometry,
pubmed-meshheading:18280607-Follow-Up Studies,
pubmed-meshheading:18280607-Hepacivirus,
pubmed-meshheading:18280607-Hepatitis C, Chronic,
pubmed-meshheading:18280607-Hepatitis C Antibodies,
pubmed-meshheading:18280607-Humans,
pubmed-meshheading:18280607-Interferon-gamma,
pubmed-meshheading:18280607-Programmed Cell Death 1 Receptor,
pubmed-meshheading:18280607-RNA, Viral,
pubmed-meshheading:18280607-T-Lymphocytes,
pubmed-meshheading:18280607-Time Factors,
pubmed-meshheading:18280607-Treatment Outcome,
pubmed-meshheading:18280607-Viremia
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pubmed:year |
2008
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pubmed:articleTitle |
Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: effect of viremia levels and antiviral treatment.
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pubmed:affiliation |
Laboratory of Viral Immunopathology, Unit of Infectious Diseases and Hepatology, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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