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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-3-17
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pubmed:abstractText |
The pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are a class of DNA minor groove binding agents that react covalently with guanine bases, preferably at Pu-G-Pu sites. A series of three fluorescent PBD-coumarin conjugates with different linker architectures has been synthesized to probe correlations between DNA binding affinity, cellular localization and cytotoxicity. The results show that the linker structure plays a critical role for all three parameters.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2147-51
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18280154-Benzodiazepines,
pubmed-meshheading:18280154-Cell Nucleus,
pubmed-meshheading:18280154-Cell Survival,
pubmed-meshheading:18280154-Cytoplasm,
pubmed-meshheading:18280154-DNA,
pubmed-meshheading:18280154-Female,
pubmed-meshheading:18280154-Humans,
pubmed-meshheading:18280154-Melanoma,
pubmed-meshheading:18280154-Microscopy, Fluorescence,
pubmed-meshheading:18280154-Molecular Structure,
pubmed-meshheading:18280154-Ovarian Neoplasms,
pubmed-meshheading:18280154-Pyrroles,
pubmed-meshheading:18280154-Tumor Cells, Cultured
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pubmed:year |
2008
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pubmed:articleTitle |
Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: synthesis, DNA interaction, cytotoxicity and differential cellular localization.
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pubmed:affiliation |
Cancer Research UK Gene Targeted Drug Design Research Group, School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, UK.
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pubmed:publicationType |
Journal Article
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