Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-3-6
pubmed:abstractText
Tissue-type plasminogen activators (tPA) and urokinase-type plasminogen activators (uPA) are involved in liver repair. We examined the potential immunomodulatory actions of uPA, tPA and uPA-receptor (uPAR) in carbon-tetrachloride-induced hepatic fibrosis in wild-type (WT), tPA-/-, uPA-/- and uPAR-/- mice. Carbon-tetrachloride treatment increased fibrosis in four groups but significantly less in three knock-out models. Serum cytokines and intrahepatic T cells elevated significantly following fibrosis process in WT animals but not in the knock-out groups. In culture, uPA increased lymphocyte proliferation significantly in WT and uPA-/- but not uPAR-/- animals. Following uPA exposure in vivo, there was CD8 predominance. To isolate uPA's effect on lymphocytes, WT mice were irradiated sublethally and then reconstituted with WT or uPA-/- lymphocytes. In these animals fibrosis was decreased and T cells were reduced in the uPA-/- recipients. Based on these data we postulate that plasminogen activators affect fibrosis in part by liver-specific activation of CD8 subsets that govern the fibrogenic activity of hepatic stellate cells.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-10551395, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-10611352, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-10644669, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-10880388, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-10961882, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-10980108, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-11025487, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-11059781, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-11238040, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-11586470, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-11733368, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-11738106, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-11848453, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-11929770, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-12016123, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-12171938, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-12183060, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-12431907, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-12466770, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-12750120, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-12927740, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-14512309, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-15356416, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-15362042, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-16141421, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-16209928, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-2521244, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-7499862, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-7908325, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-8049441, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-8133887, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-8562979, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-8611676, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-8752931, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-8796383, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-8855173, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-9005988, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-9207482, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-9380692, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-9417080, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-9425170, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-9717675, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-9743521, http://linkedlifedata.com/resource/pubmed/commentcorrection/18279442-9828225
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1365-2249
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
152
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
163-73
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:18279442-Animals, pubmed-meshheading:18279442-Mice, pubmed-meshheading:18279442-Carbon Tetrachloride, pubmed-meshheading:18279442-Male, pubmed-meshheading:18279442-Hepatocytes, pubmed-meshheading:18279442-Liver Cirrhosis, Experimental, pubmed-meshheading:18279442-Lymphocyte Transfusion, pubmed-meshheading:18279442-Cells, Cultured, pubmed-meshheading:18279442-Lymphocyte Activation, pubmed-meshheading:18279442-Whole-Body Irradiation, pubmed-meshheading:18279442-Cell Communication, pubmed-meshheading:18279442-Plasminogen Activators, pubmed-meshheading:18279442-Mice, Inbred C57BL, pubmed-meshheading:18279442-Cell Proliferation, pubmed-meshheading:18279442-Receptors, Cell Surface, pubmed-meshheading:18279442-T-Lymphocyte Subsets, pubmed-meshheading:18279442-Cytokines, pubmed-meshheading:18279442-Receptors, Urokinase Plasminogen Activator
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