| pubmed-article:1827816 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1827816 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1827816 | lifeskim:mentions | umls-concept:C1518997 | lld:lifeskim |
| pubmed-article:1827816 | lifeskim:mentions | umls-concept:C0079633 | lld:lifeskim |
| pubmed-article:1827816 | lifeskim:mentions | umls-concept:C0079720 | lld:lifeskim |
| pubmed-article:1827816 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1827816 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:1827816 | lifeskim:mentions | umls-concept:C1304884 | lld:lifeskim |
| pubmed-article:1827816 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:1827816 | pubmed:dateCreated | 1991-6-25 | lld:pubmed |
| pubmed-article:1827816 | pubmed:abstractText | We have investigated IL-8 mRNA expression and IL-8 production in highly purified subsets of peripheral blood lymphocytes. T cells stimulated with PHA, ionomycin, or PMA alone failed to express IL-8 mRNA. However T cells stimulated with a combination of PMA and ionomycin or PMA and PHA expressed IL-8 mRNA in a PMA dose-dependent manner and maximally after 3 to 6 h of culture. Induction of IL-8 mRNA appeared to be specifically in the CD4+ T cell subset. Surprisingly, however, T cells were not induced to secrete significant levels of IL-8 polypeptide, even in the presence of accessory monocytes. In addition, immunoprecipitation analysis of PMA/ionomycin-treated T cell lysates detected only minor levels of cellular IL-8 Ag thereby suggesting that in T cells, the production of IL-8 was inhibited at the posttranscriptional level. By contrast, CD3- large granular lymphocytes (LGL) were both induced to express IL-8 mRNA and secrete biologically active IL-8 upon specific stimulation with IL-2 and ligand (anti-CD16 mAb) for the NK cell receptor for IgG-Fc (CD16), or upon nonspecific stimulation with PMA. IL-2 and anti-CD16 mAb synergistically induced IL-8 expression in LGL. Other nonactivating LGL-specific mAb did not induce LGL IL-8 secretion. The amount of IL-8 produced by activated LGL was donor variable, but generally 5 to 10 times less than that secreted by monocytes. The ability of LGL to release IL-8 and a large number of other cytokines further supports the hypothesis that LGL may contribute to both inflammatory and immunologic responses. | lld:pubmed |
| pubmed-article:1827816 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1827816 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1827816 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1827816 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1827816 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1827816 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1827816 | pubmed:author | pubmed-author:OrtaldoJ RJR | lld:pubmed |
| pubmed-article:1827816 | pubmed:author | pubmed-author:MatsushimaKK | lld:pubmed |
| pubmed-article:1827816 | pubmed:author | pubmed-author:SmythM JMJ | lld:pubmed |
| pubmed-article:1827816 | pubmed:author | pubmed-author:ZachariaeC... | lld:pubmed |
| pubmed-article:1827816 | pubmed:author | pubmed-author:NorihisaYY | lld:pubmed |
| pubmed-article:1827816 | pubmed:author | pubmed-author:HishinumaAA | lld:pubmed |
| pubmed-article:1827816 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1827816 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1827816 | pubmed:volume | 146 | lld:pubmed |
| pubmed-article:1827816 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1827816 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1827816 | pubmed:pagination | 3815-23 | lld:pubmed |
| pubmed-article:1827816 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1827816 | pubmed:meshHeading | pubmed-meshheading:1827816-... | lld:pubmed |
| pubmed-article:1827816 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1827816 | pubmed:articleTitle | IL-8 gene expression and production in human peripheral blood lymphocyte subsets. | lld:pubmed |
| pubmed-article:1827816 | pubmed:affiliation | Laboratory of Experimental Immunology, NCI-FCRDC, Frederick, MD 21702-1201. | lld:pubmed |
| pubmed-article:1827816 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1827816 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1827816 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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