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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-2-25
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pubmed:abstractText |
To investigate the role of tissue plasminogen activator (tPA) in methamphetamine (METH)-induced dopaminergic neurotoxicity, we compared the changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) levels in the striatum after repetitive treatment of METH at 4 mg/kg among wild-type, tPA-deficient (tPA-/-), and protease activated receptor-1-deficient (PAR-1-/-) mice. METH treatment caused a marked decrease in TH and DAT levels in the striatum of those mice with a similar magnitude. No difference in METH-induced abnormal behavior and hyperthermia was observed among the three types of mice. These results suggest that neither tPA nor PAR-1 is involved in METH-induced dopaminergic neurotoxicity in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1347-8613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
321-4
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pubmed:meshHeading |
pubmed-meshheading:18277051-Animals,
pubmed-meshheading:18277051-Corpus Striatum,
pubmed-meshheading:18277051-Dopamine Agents,
pubmed-meshheading:18277051-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:18277051-Methamphetamine,
pubmed-meshheading:18277051-Mice,
pubmed-meshheading:18277051-Mice, Inbred C57BL,
pubmed-meshheading:18277051-Mice, Inbred ICR,
pubmed-meshheading:18277051-Mice, Knockout,
pubmed-meshheading:18277051-Neurotoxicity Syndromes,
pubmed-meshheading:18277051-Nucleus Accumbens,
pubmed-meshheading:18277051-Receptor, PAR-1,
pubmed-meshheading:18277051-Tissue Plasminogen Activator,
pubmed-meshheading:18277051-Tyrosine 3-Monooxygenase
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pubmed:year |
2008
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pubmed:articleTitle |
Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity.
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pubmed:affiliation |
Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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