|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2008-4-29
|
|
pubmed:abstractText |
Protein kinase B/Akt plays a central role in beta-cells, but little is known regarding downstream Akt substrates in these cells. Recently, Rab GTPase-activating protein AS160, a substrate of Akt, was shown to be involved in insulin modulation of GLUT4 trafficking in skeletal muscle and adipose tissue. The aim of this study was to investigate the expression and potential role of AS160 in beta-cells.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1939-327X
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
57
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1195-204
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:18276765-Animals,
pubmed-meshheading:18276765-Apoptosis,
pubmed-meshheading:18276765-Cell Division,
pubmed-meshheading:18276765-Diabetes Mellitus, Type 2,
pubmed-meshheading:18276765-Enzyme Activation,
pubmed-meshheading:18276765-GTPase-Activating Proteins,
pubmed-meshheading:18276765-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:18276765-Growth Hormone,
pubmed-meshheading:18276765-Humans,
pubmed-meshheading:18276765-Insulin-Secreting Cells,
pubmed-meshheading:18276765-Islets of Langerhans,
pubmed-meshheading:18276765-Male,
pubmed-meshheading:18276765-Mice,
pubmed-meshheading:18276765-Mice, Inbred C57BL,
pubmed-meshheading:18276765-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:18276765-RNA, Messenger,
pubmed-meshheading:18276765-RNA Interference,
pubmed-meshheading:18276765-Transfection,
pubmed-meshheading:18276765-rab GTP-Binding Proteins
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells.
|
|
pubmed:affiliation |
University Medical Center, Department of Genetic Medicine and Development, 1 Rue Michel-Servet, CH-1211 Geneva 4, Switzerland. karim.bouzakri@medecine.unige.ch
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
