Source:http://linkedlifedata.com/resource/pubmed/id/18276179
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2008-4-21
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pubmed:abstractText |
We describe a unique presentation of autosomal recessive (AR) GTP cyclohydrolase I (GTPCH) deficiency, with severe CNS involvement but without hyperphenylalaninemia. A male infant presented with progressive spasticity, dystonia and oculogyric episodes. Blood phenylalanine levels were persistently normal: whereas an oral phenylalanine loading test revealed impaired phenylalanine clearance. CSF neopterin and tetrahydrobiopterin (BH(4)) were low, homovanillic acid marginally low and 5-hydroxyindoleacetic acid normal. Fibroblasts showed decreased GTPCH enzyme activity. A homozygous novel mutation of GCH1, p.V206A, was identified. On treatment (BH(4), L-Dopa/Carbidopa and 5-hydroxytryptophan), motor development improved. Mutational analysis provided neonatal diagnosis of a younger brother who, after 18 months on treatment, shows normal development. AR GTPCH I deficiency can present without hyperphenylalaninemia and with normal or subtle CSF neurotransmitter profiles. Testing for GTPCH deficiency should be considered for patients with unexplained neurological symptoms and extrapyramidal movement disorder.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1096-7206
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
127-31
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pubmed:meshHeading |
pubmed-meshheading:18276179-Child, Preschool,
pubmed-meshheading:18276179-Consanguinity,
pubmed-meshheading:18276179-DNA Mutational Analysis,
pubmed-meshheading:18276179-Deficiency Diseases,
pubmed-meshheading:18276179-Dystonia,
pubmed-meshheading:18276179-GTP Cyclohydrolase,
pubmed-meshheading:18276179-Genes, Dominant,
pubmed-meshheading:18276179-Genes, Recessive,
pubmed-meshheading:18276179-Humans,
pubmed-meshheading:18276179-Male,
pubmed-meshheading:18276179-Mutation,
pubmed-meshheading:18276179-Phenotype,
pubmed-meshheading:18276179-Phenylalanine
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pubmed:year |
2008
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pubmed:articleTitle |
Autosomal recessive GTP cyclohydrolase I deficiency without hyperphenylalaninemia: evidence of a phenotypic continuum between dominant and recessive forms.
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pubmed:affiliation |
Department of Pediatrics, BC's Children's Hospital and University of British Columbia, 4480 Oak Street, Vancouver, BC, Canada.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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