Linked Life Data

18275619

Source:http://linkedlifedata.com/resource/pubmed/id/18275619

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-6-3
pubmed:abstractText
Traditional cardiovascular risk factors are associated with endothelial dysfunction. The vascular endothelium plays a key role in local vascular tone regulation and can be modulated by dietary fat. We propose to determine the chronic effect of three diets with different fat compositions on postprandial endothelial function and inflammatory biomarkers. Twenty healthy men followed three 4-week diets in a randomised cross-over design: a Western diet, rich in saturated fat (22% SFA, 12% MUFA and 0.4% alpha-linolenic acid (ALA), all fractions are % of energy); a Mediterranean diet, rich in MUFA ( < 10 % SFA, 24 % MUFA and 0.4% ALA); a low-fat diet enriched in ALA ( < 10% SFA, 12% MUFA and 2% ALA). At the end of each dietary period all subjects underwent a postprandial study. Plasma concentrations of lipid parameters, soluble intercellular cell-adhesion molecule-1, soluble vascular cell-adhesion molecule-1 (sVCAM-1), nitrates and nitrites (NOx) and endothelial function studied by laser Doppler were examined at 0, 2, 4, 6 and 8 h. The endothelium-dependent vasodilatory response was greater 4 h after the ingestion of the MUFA-rich diet than after the SFA or ALA low-fat diets (P = 0.031). The 4 h postprandial plasma sVCAM-1 levels were lower after the MUFA meals than after the ALA low-fat diet (P = 0.043). The bioavailability of NOx was higher following the MUFA diet than after the SFA and ALA low-fat diets (P = 0.027). We found no differences in the other parameters measured. Chronic ingestion of a Mediterranean diet avoids the postprandial deterioration of endothelial function associated with Westernised diets in healthy individuals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1475-2662
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
159-65
pubmed:dateRevised
2009-5-20
pubmed:meshHeading
pubmed-meshheading:18275619-Adolescent, pubmed-meshheading:18275619-Adult, pubmed-meshheading:18275619-Cholesterol, pubmed-meshheading:18275619-Cross-Over Studies, pubmed-meshheading:18275619-Diet, Fat-Restricted, pubmed-meshheading:18275619-Diet, Mediterranean, pubmed-meshheading:18275619-Dietary Fats, pubmed-meshheading:18275619-Endothelium, Vascular, pubmed-meshheading:18275619-Humans, pubmed-meshheading:18275619-Inflammation Mediators, pubmed-meshheading:18275619-Intercellular Adhesion Molecule-1, pubmed-meshheading:18275619-Male, pubmed-meshheading:18275619-Nutritional Physiological Phenomena, pubmed-meshheading:18275619-Plant Oils, pubmed-meshheading:18275619-Postprandial Period, pubmed-meshheading:18275619-Triglycerides, pubmed-meshheading:18275619-Vascular Cell Adhesion Molecule-1, pubmed-meshheading:18275619-Vasodilation, pubmed-meshheading:18275619-Young Adult, pubmed-meshheading:18275619-alpha-Linolenic Acid
pubmed:year
2008
pubmed:articleTitle
Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with alpha-linolenic acid on postprandial endothelial function in healthy men.
pubmed:affiliation
Lipid and Atherosclerosis Unit, Internal Medicine Service, Reina Sofía University Hospital, Avenida Menéndez Pidal s/n, Córdoba 14004, Spain. fjfuentesjimenez@yahoo.es
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't