Source:http://linkedlifedata.com/resource/pubmed/id/18275558
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-2-15
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| pubmed:abstractText |
To investigate the effects of a wake-promoting drug, modafinil on regional cerebral blood flow (rCBF) in healthy volunteers, we performed (99m)Tc-ethylcysteinate dimer single photon emission computed tomography (SPECT) before and after modafinil or placebo administration. Twenty-one healthy subjects received single doses of 400 mg modafinil or placebo in a double blind randomized crossover study design. Administrations of modafinil or placebo in a subject were separated by a 2-week washout. Brain SPECT was performed twice before and 3 h after modafinil or placebo administration. For statistical parametric mapping analysis, all SPECT images were spatially normalized to the standard SPECT template and then smoothed using a 12-mm full width at half-maximum Gaussian kernel. The paired t-test was used to compare pre- versus post-modafinil and pre- versus post-placebo SPECT images. Differences in rCBF between post-modafinil and post-placebo conditions were also tested. Modafinil decreased Epworth and Stanford sleepiness scales whereas placebo did not. The post-modafinil condition was associated with increased rCBF in bilateral thalami and dorsal pons, whereas the post-placebo condition showed increased rCBF in a smaller area of the dorsal pons when compared with the drug naïve baseline condition. Compared with the post-placebo condition, the post-modafinil condition showed higher rCBF in bilateral frontopolar, orbitofrontal, superior frontal, middle frontal gyri, short insular gyri, left cingulate gyrus, left middle/inferior temporal gyri, left parahippocampal gyrus, and left pons. In healthy volunteers, modafinil increased wakefulness and rCBF in the arousal-related systems and in brain areas related to emotion and executive function.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1365-2869
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
17
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
82-8
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| pubmed:meshHeading |
pubmed-meshheading:18275558-Acoustic Stimulation,
pubmed-meshheading:18275558-Adult,
pubmed-meshheading:18275558-Benzhydryl Compounds,
pubmed-meshheading:18275558-Brain,
pubmed-meshheading:18275558-Central Nervous System Stimulants,
pubmed-meshheading:18275558-Cerebrovascular Circulation,
pubmed-meshheading:18275558-Cross-Over Studies,
pubmed-meshheading:18275558-Disorders of Excessive Somnolence,
pubmed-meshheading:18275558-Double-Blind Method,
pubmed-meshheading:18275558-Epilepsy, Temporal Lobe,
pubmed-meshheading:18275558-Female,
pubmed-meshheading:18275558-Glucose,
pubmed-meshheading:18275558-Humans,
pubmed-meshheading:18275558-Limbic System,
pubmed-meshheading:18275558-Male,
pubmed-meshheading:18275558-Narcolepsy,
pubmed-meshheading:18275558-Photic Stimulation,
pubmed-meshheading:18275558-Reaction Time,
pubmed-meshheading:18275558-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:18275558-Wakefulness
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| pubmed:year |
2008
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| pubmed:articleTitle |
Cerebral blood flow changes in man by wake-promoting drug, modafinil: a randomized double blind study.
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| pubmed:affiliation |
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
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| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|