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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-3-3
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pubmed:abstractText |
Identification of the molecular targets for post-translational modifications is an important step for explaining the regulated pathways. The ubiquitin-like molecule NEDD8 is implicated in the regulation of cell proliferation, viability and development. By combining proteomics and in vivo NEDDylation assays, we identified a subset of ribosomal proteins as novel targets for the NEDD8 pathway. We further show that the lack of NEDDylation in cells causes ribosomal protein instability. Our studies identify a novel and specific role of the NEDD8 pathway in protecting a subset of ribosomal proteins from destabilization.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-10504710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-10891491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-11285283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-11526482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-12730221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-15021886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-15060148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-15152193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-15242646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-15567417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-15635413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-15742198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-15775960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-16056266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-16328431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-16620772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-16735510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-16753028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-16762551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-16980297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-16998474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18274552-17446074
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1469-221X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
280-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
Ribosomal proteins are targets for the NEDD8 pathway.
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pubmed:affiliation |
Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK. d.xirodimas@dundee.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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