Linked Life Data

1827378

Source:http://linkedlifedata.com/resource/pubmed/id/1827378

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-6-10
pubmed:abstractText
Several authors point to a different action of soluble insulin when mixed with a lente formulation containing either protamine or zinc. We evaluated glucose and insulin profiles in 17 type I diabetics, every one of whom was given what was considered the optimal amount of insulin twenty minutes before a standard evening meal. The patients were studied on two occasions, one week apart. According to a randomized sequence, those who received first the protamine-soluble mixture, took the Zn-soluble combination after one week and vice-versa. At the same time, we determined anti-insulin antibodies in order to rule out any different immunological interference, in the two moments of the study. Our results confirm that protamine-insulin given together with regular shows a serum insulin peak which is earlier and higher than that obtained with the corresponding mixture of Zn-insulin and regular (ANOVA: F = 5, 96; p = 0.02); blood glucose levels were lower with the former regimen, even though the difference did not reach statistical significance. Our conclusion is that Zn-containing insulin partly inactivates regular insulin when administered in the same syringe, and this may have an impact on the long-term treatment of the diabetic patient.
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0009-9074
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
136
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-100
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
[Absorption of short-acting insulin mixed with different slow-release formulations].
pubmed:affiliation
Divisione di Medicina, Ospedale Civile di Vigevano.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, English Abstract, Randomized Controlled Trial