18272499

Source:http://linkedlifedata.com/resource/pubmed/id/18272499

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0868939, umls-concept:C1441759
pubmed:issue	7
pubmed:dateCreated	2008-2-21
pubmed:abstractText	We present the fabrication of nanoscale electroactive thin films that can be engineered to undergo remotely controlled dissolution in the presence of a small applied voltage (+1.25 V) to release precise quantities of chemical agents. These films, which are assembled by using a nontoxic, FDA-approved, electroactive material known as Prussian Blue, are stable enough to release a fraction of their contents after the application of a voltage and then to restabilize upon its removal. As a result, it is possible to externally trigger agent release, exert control over the relative quantity of agents released from a film, and release multiple doses from one or more films in a single solution. These electroactive systems may be rapidly and conformally coated onto a wide range of substrates without regard to size, shape, or chemical composition, and as such they may find use in a host of new applications in drug delivery as well as the related fields of tissue engineering, medical diagnostics, and chemical detection.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/18272499-11710050, http://linkedlifedata.com/resource/pubmed/commentcorrection/18272499-12440887, http://linkedlifedata.com/resource/pubmed/commentcorrection/18272499-14520404, http://linkedlifedata.com/resource/pubmed/commentcorrection/18272499-14741115, http://linkedlifedata.com/resource/pubmed/commentcorrection/18272499-15350066, http://linkedlifedata.com/resource/pubmed/commentcorrection/18272499-15697314, http://linkedlifedata.com/resource/pubmed/commentcorrection/18272499-16715375, http://linkedlifedata.com/resource/pubmed/commentcorrection/18272499-16801543, http://linkedlifedata.com/resource/pubmed/commentcorrection/18272499-16921362, http://linkedlifedata.com/resource/pubmed/commentcorrection/18272499-2470825, http://linkedlifedata.com/resource/pubmed/commentcorrection/18272499-8045465, http://linkedlifedata.com/resource/pubmed/commentcorrection/18272499-9811495, http://linkedlifedata.com/resource/pubmed/commentcorrection/18272499-9988626
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7505876
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Dextran Sulfate, http://linkedlifedata.com/resource/pubmed/chemical/Ferrocyanides, http://linkedlifedata.com/resource/pubmed/chemical/ferric ferrocyanide
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1091-6490
pubmed:author	pubmed-author:AndayaBrian JBJ, pubmed-author:HammondPaula TPT, pubmed-author:SchmidtDaniel JDJ, pubmed-author:WoodKris CKC, pubmed-author:WrightmanStefani NSN, pubmed-author:ZachariaNicole SNS
pubmed:issnType	Electronic
pubmed:day	19
pubmed:volume	105
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2280-5
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:18272499-Dextran Sulfate, pubmed-meshheading:18272499-Electrochemistry, pubmed-meshheading:18272499-Electrons, pubmed-meshheading:18272499-Ferrocyanides, pubmed-meshheading:18272499-Nanocomposites
pubmed:year	2008
pubmed:articleTitle	Electroactive controlled release thin films.
pubmed:affiliation	Departments of Chemical Engineering and Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't