rdf:type |
|
lifeskim:mentions |
umls-concept:C0011155,
umls-concept:C0024141,
umls-concept:C0030705,
umls-concept:C0034897,
umls-concept:C0040053,
umls-concept:C0056193,
umls-concept:C0072393,
umls-concept:C0441889,
umls-concept:C1264633,
umls-concept:C1299351,
umls-concept:C1880497,
umls-concept:C1996904
|
pubmed:issue |
1
|
pubmed:dateCreated |
1991-6-3
|
pubmed:abstractText |
A patient with systemic lupus erythematosus and numerous thrombotic accidents was found to have a deficiency of the free fraction of protein S, most likely due to an abnormally high level of C4b binding protein. These abnormalities, unique in comparison to 4 other patients with hypercoagulation states, were partially corrected with cyclophosphamide. There was no evidence of a consumption of complement components. The interactions between the hemostasis system and the complement cascade are discussed.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0315-162X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
18
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
82-7
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:1827159-Adult,
pubmed-meshheading:1827159-Blood Proteins,
pubmed-meshheading:1827159-Carrier Proteins,
pubmed-meshheading:1827159-Complement C4b,
pubmed-meshheading:1827159-Complement Inactivator Proteins,
pubmed-meshheading:1827159-Cyclophosphamide,
pubmed-meshheading:1827159-Female,
pubmed-meshheading:1827159-Glycoproteins,
pubmed-meshheading:1827159-Humans,
pubmed-meshheading:1827159-Immunoelectrophoresis, Two-Dimensional,
pubmed-meshheading:1827159-Lupus Erythematosus, Systemic,
pubmed-meshheading:1827159-Protein S,
pubmed-meshheading:1827159-Recurrence,
pubmed-meshheading:1827159-Thrombosis
|
pubmed:year |
1991
|
pubmed:articleTitle |
Abnormally high level of C4b binding protein and deficiency of free fraction of protein S in a patient with systemic lupus erythematosus and recurrent thromboses.
|
pubmed:affiliation |
Division of Hematology/Oncology, Memorial Hospital of Rhode Island, Pawtucket 02860.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports
|