| pubmed-article:1827138 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1827138 | lifeskim:mentions | umls-concept:C0759310 | lld:lifeskim |
| pubmed-article:1827138 | lifeskim:mentions | umls-concept:C0009015 | lld:lifeskim |
| pubmed-article:1827138 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:1827138 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:1827138 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:1827138 | lifeskim:mentions | umls-concept:C1332711 | lld:lifeskim |
| pubmed-article:1827138 | lifeskim:mentions | umls-concept:C1420642 | lld:lifeskim |
| pubmed-article:1827138 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:1827138 | lifeskim:mentions | umls-concept:C0086222 | lld:lifeskim |
| pubmed-article:1827138 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:1827138 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:1827138 | lifeskim:mentions | umls-concept:C1705733 | lld:lifeskim |
| pubmed-article:1827138 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1827138 | pubmed:dateCreated | 1991-6-4 | lld:pubmed |
| pubmed-article:1827138 | pubmed:abstractText | CD3-epsilon gene expression is confined to the T cell lineage. We have recently identified and cloned a human transcription factor, TCF-1, that binds to a functional element in the T lymphocyte-specific enhancer of CD3-epsilon. In a panel of human cell lines, TCF-1 expression was restricted to T lineage cells. TCF-1 belonged to a novel family of genes that contain the so-called high mobility group 1 (HMG) box. Here we report the cloning of murine TCF-1. Two splice alternatives were identified that were not previously observed in human TCF-1. Murine and human TCF-1 displayed a 95.5% overall amino acid homology. Recombinant murine and human TCF-1 recognized the same sequence motif in the CD3-epsilon enhancer as judged by gel retardation and methylation interference assays. With the murine cDNA clones several aspects of TCF-1 were analyzed. First, deletion analysis revealed that a region of TCF-1 containing the HMG box was sufficient for sequence-specific binding. Second, by high stringency Northern blotting and in situ hybridization, TCF-1 expression was shown to be confined to the thymus and to the T cell areas of the spleen. Third, TCF-1 bound specifically to a functional T cell-specific element in the T cell receptor alpha (TCR-alpha) enhancer. The T lineage-specific expression and the affinity for functional motifs in the TCR-alpha and CD3-epsilon enhancers imply an important role for TCF-1 in the establishment of the mature T cell phenotype. | lld:pubmed |
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| pubmed-article:1827138 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1827138 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1827138 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1827138 | pubmed:month | May | lld:pubmed |
| pubmed-article:1827138 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:1827138 | pubmed:author | pubmed-author:WinotoAA | lld:pubmed |
| pubmed-article:1827138 | pubmed:author | pubmed-author:CleversHH | lld:pubmed |
| pubmed-article:1827138 | pubmed:author | pubmed-author:OosterwegelMM | lld:pubmed |
| pubmed-article:1827138 | pubmed:author | pubmed-author:MeijlinkFF | lld:pubmed |
| pubmed-article:1827138 | pubmed:author | pubmed-author:GeorgopoulosK... | lld:pubmed |
| pubmed-article:1827138 | pubmed:author | pubmed-author:van de... | lld:pubmed |
| pubmed-article:1827138 | pubmed:author | pubmed-author:DooijesDD | lld:pubmed |
| pubmed-article:1827138 | pubmed:author | pubmed-author:KlompLL | lld:pubmed |
| pubmed-article:1827138 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1827138 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1827138 | pubmed:volume | 173 | lld:pubmed |
| pubmed-article:1827138 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1827138 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1827138 | pubmed:pagination | 1133-42 | lld:pubmed |
| pubmed-article:1827138 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1827138 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1827138 | pubmed:articleTitle | Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers. | lld:pubmed |
| pubmed-article:1827138 | pubmed:affiliation | Department of Clinical Immunology, University Hospital Utrecht, The Netherlands. | lld:pubmed |
| pubmed-article:1827138 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1827138 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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