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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-3-20
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pubmed:abstractText |
Insulin secretion in pancreatic islets is dependent upon mitochondrial function and production of ATP. The transcriptional coactivator peroxisome proliferator activated receptor gamma coactivator-1 alpha (protein PGC-1alpha; gene PPARGC1A) is a master regulator of mitochondrial genes and its expression is decreased and related to impaired oxidative phosphorylation in muscle from patients with type 2 diabetes. Whether it plays a similar role in human pancreatic islets is not known. We therefore investigated if PPARGC1A expression is altered in islets from patients with type 2 diabetes and whether this expression is influenced by genetic (PPARGC1A Gly482Ser polymorphism) and epigenetic (DNA methylation) factors. We also tested if experimental downregulation of PPARGC1A expression in human islets influenced insulin secretion.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-10580437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-10958757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-11325516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-11723056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-11793024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-11815472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-12606537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-12808457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-12832613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-12852853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-15111510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-15546003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-15734849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-16054085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-16435105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-16648099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-2996187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-8528247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18270681-9519717
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0012-186X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
615-22
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18270681-Animals,
pubmed-meshheading:18270681-DNA Methylation,
pubmed-meshheading:18270681-Diabetes Mellitus, Experimental,
pubmed-meshheading:18270681-Diabetes Mellitus, Type 2,
pubmed-meshheading:18270681-Gene Expression Regulation,
pubmed-meshheading:18270681-Genotype,
pubmed-meshheading:18270681-Heat-Shock Proteins,
pubmed-meshheading:18270681-Humans,
pubmed-meshheading:18270681-Insulin,
pubmed-meshheading:18270681-Islets of Langerhans,
pubmed-meshheading:18270681-Male,
pubmed-meshheading:18270681-Mitochondria,
pubmed-meshheading:18270681-Polymerase Chain Reaction,
pubmed-meshheading:18270681-RNA, Messenger,
pubmed-meshheading:18270681-RNA, Small Interfering,
pubmed-meshheading:18270681-Rats,
pubmed-meshheading:18270681-Rats, Wistar,
pubmed-meshheading:18270681-Reference Values,
pubmed-meshheading:18270681-Tissue Donors,
pubmed-meshheading:18270681-Transcription Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.
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pubmed:affiliation |
Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, CRC, 205 02 Malmö, Sweden. charlotte.ling@med.lu.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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