Linked Life Data

18270515

Source:http://linkedlifedata.com/resource/pubmed/id/18270515

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-2-20
pubmed:abstractText
Pyramidal neurons are characterized by their distinct apical and basal dendritic trees and the pyramidal shape of their soma. They are found in several regions of the CNS and, although the reasons for their abundance remain unclear, functional studies--especially of CA1 hippocampal and layer V neocortical pyramidal neurons--have offered insights into the functions of their unique cellular architecture. Pyramidal neurons are not all identical, but some shared functional principles can be identified. In particular, the existence of dendritic domains with distinct synaptic inputs, excitability, modulation and plasticity appears to be a common feature that allows synapses throughout the dendritic tree to contribute to action-potential generation. These properties support a variety of coincidence-detection mechanisms, which are likely to be crucial for synaptic integration and plasticity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1471-0048
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
206-21
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Pyramidal neurons: dendritic structure and synaptic integration.
pubmed:affiliation
Northwestern University, Department of Neurobiology & Physiology, 2205 Tech Drive, Evanston, Illinois 60208, USA. spruston@northwestern.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural