| pubmed-article:18266910 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18266910 | lifeskim:mentions | umls-concept:C0242608 | lld:lifeskim |
| pubmed-article:18266910 | lifeskim:mentions | umls-concept:C0008546 | lld:lifeskim |
| pubmed-article:18266910 | lifeskim:mentions | umls-concept:C1257825 | lld:lifeskim |
| pubmed-article:18266910 | lifeskim:mentions | umls-concept:C0012120 | lld:lifeskim |
| pubmed-article:18266910 | lifeskim:mentions | umls-concept:C0218063 | lld:lifeskim |
| pubmed-article:18266910 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18266910 | pubmed:dateCreated | 2008-4-14 | lld:pubmed |
| pubmed-article:18266910 | pubmed:abstractText | The centrosome-nucleus attachment is a prerequisite for faithful chromosome segregation during mitosis. We addressed the function of the nuclear envelope (NE) protein Sun-1 in centrosome-nucleus connection and the maintenance of genome stability in Dictyostelium discoideum. We provide evidence that Sun-1 requires direct chromatin binding for its inner nuclear membrane targeting. Truncation of the cryptic N-terminal chromatin-binding domain of Sun-1 induces dramatic separation of the inner from the outer nuclear membrane and deformations in nuclear morphology, which are also observed using a Sun-1 RNAi construct. Thus, chromatin binding of Sun-1 defines the integrity of the nuclear architecture. In addition to its role as a NE scaffold, we find that abrogation of the chromatin binding of Sun-1 dissociates the centrosome-nucleus connection, demonstrating that Sun-1 provides an essential link between the chromatin and the centrosome. Moreover, loss of the centrosome-nucleus connection causes severe centrosome hyperamplification and defective spindle formation, which enhances aneuploidy and cell death significantly. We highlight an important new aspect for Sun-1 in coupling the centrosome and nuclear division during mitosis to ensure faithful chromosome segregation. | lld:pubmed |
| pubmed-article:18266910 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18266910 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18266910 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18266910 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18266910 | pubmed:month | May | lld:pubmed |
| pubmed-article:18266910 | pubmed:issn | 1600-0854 | lld:pubmed |
| pubmed-article:18266910 | pubmed:author | pubmed-author:NoegelAngelik... | lld:pubmed |
| pubmed-article:18266910 | pubmed:author | pubmed-author:RiveroFrancis... | lld:pubmed |
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| pubmed-article:18266910 | pubmed:author | pubmed-author:Mana-CapelliS... | lld:pubmed |
| pubmed-article:18266910 | pubmed:author | pubmed-author:VogelAnnetteA | lld:pubmed |
| pubmed-article:18266910 | pubmed:author | pubmed-author:LarochelleDen... | lld:pubmed |
| pubmed-article:18266910 | pubmed:author | pubmed-author:MondalSubhanj... | lld:pubmed |
| pubmed-article:18266910 | pubmed:author | pubmed-author:XiongHuajiang... | lld:pubmed |
| pubmed-article:18266910 | pubmed:author | pubmed-author:GassenBerthol... | lld:pubmed |
| pubmed-article:18266910 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18266910 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:18266910 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18266910 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18266910 | pubmed:pagination | 708-24 | lld:pubmed |
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| pubmed-article:18266910 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18266910 | pubmed:articleTitle | Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability. | lld:pubmed |
| pubmed-article:18266910 | pubmed:affiliation | Center for Biochemistry I, Medical Faculty, University of Cologne, Joseph-Stelzmann-Strasse 52, 50931 Cologne, Germany. | lld:pubmed |
| pubmed-article:18266910 | pubmed:publicationType | Journal Article | lld:pubmed |
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