Linked Life Data

18266055

Source:http://linkedlifedata.com/resource/pubmed/id/18266055

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-3-4
pubmed:abstractText
Previous studies indicated that region 11.2 of the long arm of chromosome 22 (22q11.2) might be a locus encoding a tumor suppressor gene, since its deletion is a recurrent genetic characteristic of aggressive pediatric cancer. This region is found in the human immunodeficiency virus integrase interactor 1 (hSNF5/INI1) gene. To investigate whether the hSNF5/INI1 gene is involved in leukemogenesis, mutation analysis of the hSNF5/INI1 gene was performed in the present study using 5 hematopoietic cell lines, acute myeloid leukemia (AML) specimen and normal control. We found two single nucleotide polymorphisms at the hSNF5/INI1 gene in exon 4 and exon 9. The results of this study suggest that the hSNF5/INI1 gene does not play an important role in the leukemogenesis of AML.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0925-5710
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
172-5
pubmed:dateRevised
2008-12-29
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
hSNF5 /INI1 mutation analysis in acute myeloid leukemia.
pubmed:affiliation
Division of Hematology-Oncology, Department of Internal Medicine, Buddhist Dalin TzuChi General Hospital, Chiayi County, Taiwan. hepatoma@ms3.hinet.net
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't