Source:http://linkedlifedata.com/resource/pubmed/id/18264743
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2008-3-4
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| pubmed:abstractText |
To investigate the association between graft-versus-host disease (GVHD) and renal injury after allogeneic stem cell transplantation (allo-SCT), we compared autopsy findings of 26 consecutive allo-SCT recipients with two control groups: patients with hematologic malignancies who received cytotoxic chemotherapy alone (Control 1, n = 21) and those with non-hematologic diseases (Control 2, n = 12). We evaluated the following renal pathology; renal tubulitis, allograft glomerulitis, intimal arteritis, allograft nephropathy, and peritubular capillaritis. These changes were found in 11 allo-SCT recipients and 10 patients in Control 1, but none in Control 2. While overall frequency of renal impairments was similar between allo-SCT recipients and Control 1 (3/26 vs. 1/21), allo-SCT recipients were more likely to have renal tubulitis and peritubular capillaritis compared to Control 1 (5/26 vs. 1/21), but less likely to present with glomerulitis (1/26 vs. 6/21). Grade III-IV acute or extensive-type chronic GVHD were seen in all of the three patients with renal tubulitis and four of the five patients with peritubular capillaritis. Allo-SCT recipients with severe GVHD tended to have tubulitis and peritubular capillaritis. These findings have implications of some renal impairment attributable to GVHD.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0925-5710
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| pubmed:author |
pubmed-author:HaraShigeoS,
pubmed-author:HoshinoJunichiJ,
pubmed-author:KamiMasahiroM,
pubmed-author:KishiYukikoY,
pubmed-author:KusumiEijiE,
pubmed-author:MasuokaKazuhiroK,
pubmed-author:MatsumuraTomokoT,
pubmed-author:MiyakoshiShigesaburoS,
pubmed-author:MurashigeNaokoN,
pubmed-author:ShibagakiYugoY,
pubmed-author:ShibataTaroT,
pubmed-author:TaniguchiShuichiS,
pubmed-author:WakeAtsushiA,
pubmed-author:YamaguchiYutakaY,
pubmed-author:YujiKoichiroK
|
| pubmed:issnType |
Print
|
| pubmed:volume |
87
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
225-30
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| pubmed:meshHeading |
pubmed-meshheading:18264743-Adolescent,
pubmed-meshheading:18264743-Adult,
pubmed-meshheading:18264743-Aged,
pubmed-meshheading:18264743-Case-Control Studies,
pubmed-meshheading:18264743-Female,
pubmed-meshheading:18264743-Graft vs Host Disease,
pubmed-meshheading:18264743-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:18264743-Humans,
pubmed-meshheading:18264743-Kidney,
pubmed-meshheading:18264743-Kidney Diseases,
pubmed-meshheading:18264743-Male,
pubmed-meshheading:18264743-Middle Aged,
pubmed-meshheading:18264743-Transplantation, Homologous
|
| pubmed:year |
2008
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| pubmed:articleTitle |
Postmortem examination of the kidney in allogeneic hematopoietic stem cell transplantation recipients: possible involvement of graft-versus-host disease.
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| pubmed:affiliation |
Department of Hematology, Toranomon Hospital, Tokyo, Japan.
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| pubmed:publicationType |
Journal Article
|