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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-4-1
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pubmed:abstractText |
In animal models, brain-derived neurotrophic factor (BDNF) appears to protect against cerebral ischemia. The authors examined whether the BDNF Val66Met polymorphism, which affects BDNF distribution, was associated with greater volumes of hyperintense lesions as detected on magnetic resonance imaging in a cohort of depressed and nondepressed elders.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1545-7214
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
263-71
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pubmed:meshHeading |
pubmed-meshheading:18263664-Age of Onset,
pubmed-meshheading:18263664-Aged,
pubmed-meshheading:18263664-Amino Acid Substitution,
pubmed-meshheading:18263664-Brain,
pubmed-meshheading:18263664-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:18263664-Cross-Sectional Studies,
pubmed-meshheading:18263664-Depression,
pubmed-meshheading:18263664-Female,
pubmed-meshheading:18263664-Genotype,
pubmed-meshheading:18263664-Humans,
pubmed-meshheading:18263664-Magnetic Resonance Imaging,
pubmed-meshheading:18263664-Male,
pubmed-meshheading:18263664-Methionine,
pubmed-meshheading:18263664-Polymorphism, Single Nucleotide,
pubmed-meshheading:18263664-Valine
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pubmed:year |
2008
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pubmed:articleTitle |
The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression.
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pubmed:affiliation |
Neuropsychiatric Imaging Research Laboratory, and the Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA. Taylo066@mc.duke.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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