Linked Life Data

18262770

Source:http://linkedlifedata.com/resource/pubmed/id/18262770

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2008-5-2
pubmed:abstractText
Diffusion Tensor Imaging (DTI) investigations in schizophrenia have provided evidence of impairment in white matter as indicated by reduced fractional anisotropy (FA). However, the neuropathological implications of these findings remain unclear. In the current study, we conducted a voxelwise analysis of the constituent parameters of FA, Axial (lambda(||)) and Radial Diffusivity (lambda( upper left and right quadrants)), in 14 male participants with schizophrenia and 14 age, gender, education, and premorbid intelligence matched healthy controls. Significantly reduced FA and higher Radial Diffusivity were concurrently observed in several major white matter tracts in the schizophrenia group. This finding suggests that the loss of white matter integrity in schizophrenia is the result of demyelination and/or changes to the axonal cytoskeleton rather than gross axonal damage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0920-9964
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
106-10
pubmed:dateRevised
2010-9-2
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Abnormal white matter microstructure in schizophrenia: a voxelwise analysis of axial and radial diffusivity.
pubmed:affiliation
Melbourne Neuropsychiatry Centre, The University of Melbourne, Victoria, Australia. mseal@unimelb.edu.au
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't