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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-3-14
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pubmed:abstractText |
The development of neuronal polarity is essential for the determination of neuron connectivity and for correct brain function. The c-Jun N-terminal kinase (JNK)-interacting protein-1 (JIP1) is highly expressed in neurons and has previously been characterized as a regulator of JNK signaling.JIP1 has been shown to localize to neurites in various neuronal models, but the functional significance of this localization is not fully understood [1-4]. JIP1 is also a cargo of the motor protein kinesin-1, which is important for axonal transport [2, 4]. Here we demonstrate that before primary cortical neurons become polarized, JIP1 specifically localizes to a single neurite and that after axonal specification,it accumulates in the emerging axon. JIP1 is necessary for normal axonal development and promotes axonal growth dependent upon its binding to kinesin-1 and via a newly described interaction with the c-Abl tyrosine kinase. JIP1associates with and is phosphorylated by c-Abl, and the mutation of the c-Abl phosphorylation site on JIP1 abrogates its ability to promote axonal growth. JIP1 is therefore an important regulator of axonal development and is a key target of c-Abl-dependent pathways that control axonal growth.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-10679439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-10712642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-10896159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-10908620,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-11562351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-11864995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-12417580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-12756254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-12824383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-14515362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-14630215,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-15572149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-15790972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-15856056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-15935771,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-17052208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-17084703,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18261906-3313064
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
The JIP1 scaffold protein regulates axonal development in cortical neurons.
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pubmed:affiliation |
Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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