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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-3-17
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pubmed:abstractText |
Bone marrow (BM) Th1 populations can contribute to graft-vs-leukemia responses. Granulocyte/granulocyte macrophage colony-stimulating factor (CSF)-mobilized peripheral blood progenitor cells (PBPC) have become widely accepted alternatives to BM transplantation. T cells coexpressing natural killer cell proteins (NKT) include a CD1d-reactive subset that influences immunity by rapidly producing large amounts of Th1 and/or Th2 cytokines dependent upon microenvironment and disease. There are two types of CD1d-reactive NKT. iNKT express a semi-invariant T-cell receptor-alpha. Other noninvariant CD1d-reactive NKT from BM and liver produce large amounts of interleukin-4 or interferon-gamma, respectively, and within the intestine can be biased in either direction. Recent data suggests that NKT might contribute to clinical benefits of PBPC.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-10190898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-10553057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-10586039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-10733495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-10887344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-11564825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-11698421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-11823474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-12860168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-1386094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-14513412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-1467527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-14970932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-15146247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-15265953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-15470038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-15545985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-15611282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-16002737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-16192477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-16210612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-16365146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-16373666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-17379092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-17475852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-7537116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-9116306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-9207002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18261838-9730888
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
464-72
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pubmed:dateRevised |
2011-4-4
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pubmed:meshHeading |
pubmed-meshheading:18261838-Adult,
pubmed-meshheading:18261838-Antigens, CD1,
pubmed-meshheading:18261838-Antigens, CD1d,
pubmed-meshheading:18261838-Cell Separation,
pubmed-meshheading:18261838-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:18261838-Hematopoietic Stem Cells,
pubmed-meshheading:18261838-Hodgkin Disease,
pubmed-meshheading:18261838-Humans,
pubmed-meshheading:18261838-Immunophenotyping,
pubmed-meshheading:18261838-Killer Cells, Natural,
pubmed-meshheading:18261838-Lymphoma, Non-Hodgkin,
pubmed-meshheading:18261838-Middle Aged,
pubmed-meshheading:18261838-Multiple Myeloma,
pubmed-meshheading:18261838-Stem Cell Transplantation,
pubmed-meshheading:18261838-Survival Rate,
pubmed-meshheading:18261838-Th1 Cells,
pubmed-meshheading:18261838-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
Peripheral blood progenitor cell product contains Th1-biased noninvariant CD1d-reactive natural killer T cells: implications for posttransplant survival.
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pubmed:affiliation |
Department of Hematology-Oncology Beth Israel-Deaconess Medical Center, Boston, Mass. 02215, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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