Linked Life Data

18261828

Source:http://linkedlifedata.com/resource/pubmed/id/18261828

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2009-8-31
pubmed:abstractText
In vivo measurement of cortical thickness is a sensitive representation of pathology in neurodegenerative disorders which primarily target the gray mantle. In this study we used magnetic resonance images to describe the patterns of cortical thinning in 11 frontotemporal dementia (FTD), 38 Alzheimer's disease (AD) and 34 healthy elderly (H(E)) subjects. AD and FTD displayed significant thinning of the cortical mantle compared to the H(E) group, but with distinctive distributions. AD subjects had significantly thinner cortex in all lobes whereas FTD compared to H(E) showed significant differences only in specific regions of frontal and temporal lobes. When compared to AD, the FTD subjects had a trend of thinner cortex in the anterior cingulate region and in selective regions of anterior frontal and temporal regions. In conclusion, the cortical thinning in dementia when compared to H(E), is disease specific whereby FTD subjects display a pattern distinct than that seen in Alzheimer's disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1558-1497
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1626-36
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia.
pubmed:affiliation
Sunnybrook Health Sciences Centre, 3080 Yonge Street, Suite 6020, Toronto, Ontario M4N 3N1, Canada. blake.richards@psy.ox.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't