Linked Life Data

1825912

Source:http://linkedlifedata.com/resource/pubmed/id/1825912

Statements in which the resource exists.
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pubmed-article:1825912pubmed:abstractTextPolyreactive systemic lupus erythematosus (SLE) B cells were compared with antigen-induced SLE and normal B cells for their interleukin-6 (IL-6) and soluble CD23 requirements. Unlike normal B cells, secretion of antibody by SLE B cells in serum-free medium was not enhanced by exogenous IL-6. Anti-IL-6 antibodies inhibited immunoglobulin production in cultures of normal and SLE B cells, which suggests that IL-6 is required for B cell differentiation. SLE culture supernatants had elevated levels of IL-6, which explains the poor response of the SLE cells to exogenous IL-6. Soluble CD23 enhanced the responses of cells from normal subjects and SLE patients.lld:pubmed
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pubmed-article:1825912pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:1825912pubmed:articleTitleIn vitro regulation of B cell differentiation by interleukin-6 and soluble CD23 in systemic lupus erythematosus B cell subpopulations and antigen-induced normal B cells.lld:pubmed
pubmed-article:1825912pubmed:affiliationDepartment of Medicine, University of California, Los Angeles School of Medicine 90024.lld:pubmed
pubmed-article:1825912pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1825912pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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