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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-4-12
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pubmed:abstractText |
Polyreactive systemic lupus erythematosus (SLE) B cells were compared with antigen-induced SLE and normal B cells for their interleukin-6 (IL-6) and soluble CD23 requirements. Unlike normal B cells, secretion of antibody by SLE B cells in serum-free medium was not enhanced by exogenous IL-6. Anti-IL-6 antibodies inhibited immunoglobulin production in cultures of normal and SLE B cells, which suggests that IL-6 is required for B cell differentiation. SLE culture supernatants had elevated levels of IL-6, which explains the poor response of the SLE cells to exogenous IL-6. Soluble CD23 enhanced the responses of cells from normal subjects and SLE patients.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
276-86
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1825912-Adult,
pubmed-meshheading:1825912-Antibody Formation,
pubmed-meshheading:1825912-Antigens, CD,
pubmed-meshheading:1825912-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:1825912-B-Lymphocyte Subsets,
pubmed-meshheading:1825912-B-Lymphocytes,
pubmed-meshheading:1825912-Cell Differentiation,
pubmed-meshheading:1825912-Female,
pubmed-meshheading:1825912-Humans,
pubmed-meshheading:1825912-Immunization,
pubmed-meshheading:1825912-Interleukin-6,
pubmed-meshheading:1825912-Lupus Erythematosus, Systemic,
pubmed-meshheading:1825912-Male,
pubmed-meshheading:1825912-Middle Aged,
pubmed-meshheading:1825912-Receptors, Fc,
pubmed-meshheading:1825912-Receptors, IgE,
pubmed-meshheading:1825912-Solubility,
pubmed-meshheading:1825912-Tetanus Toxoid
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pubmed:year |
1991
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pubmed:articleTitle |
In vitro regulation of B cell differentiation by interleukin-6 and soluble CD23 in systemic lupus erythematosus B cell subpopulations and antigen-induced normal B cells.
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pubmed:affiliation |
Department of Medicine, University of California, Los Angeles School of Medicine 90024.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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