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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-2-25
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pubmed:abstractText |
Although epidemiologic data suggest that hypertriglyceridemia and elevated plasma levels of fatty acids are toxic to arteries, in vitro correlates have been inconsistent. To investigate whether increased endothelial cell expression of lipoprotein lipase (LpL), the primary enzyme creating free fatty acids from circulating triglycerides (TG), affects vascular function, we created transgenic mice that express human LpL (hLpL) driven by the promoter and enhancer of the Tie2 receptor.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
455-62
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pubmed:meshHeading |
pubmed-meshheading:18258818-Animals,
pubmed-meshheading:18258818-Cells, Cultured,
pubmed-meshheading:18258818-Disease Models, Animal,
pubmed-meshheading:18258818-Endothelial Cells,
pubmed-meshheading:18258818-Gene Expression,
pubmed-meshheading:18258818-Genotype,
pubmed-meshheading:18258818-Humans,
pubmed-meshheading:18258818-Hypertriglyceridemia,
pubmed-meshheading:18258818-Immunohistochemistry,
pubmed-meshheading:18258818-Lipoprotein Lipase,
pubmed-meshheading:18258818-Lipoproteins, VLDL,
pubmed-meshheading:18258818-Mice,
pubmed-meshheading:18258818-Mice, Knockout,
pubmed-meshheading:18258818-Mice, Transgenic,
pubmed-meshheading:18258818-Random Allocation,
pubmed-meshheading:18258818-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18258818-Transfection,
pubmed-meshheading:18258818-Triglycerides,
pubmed-meshheading:18258818-Tumor Necrosis Factor-alpha,
pubmed-meshheading:18258818-Vasculitis,
pubmed-meshheading:18258818-Vasodilation
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pubmed:year |
2008
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pubmed:articleTitle |
In vivo arterial lipoprotein lipase expression augments inflammatory responses and impairs vascular dilatation.
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pubmed:affiliation |
Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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