Source:http://linkedlifedata.com/resource/pubmed/id/18258801
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2008-4-3
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pubmed:abstractText |
Brain-derived natriuretic peptide (BNP) is a cardioprotective peptide released, together with the inactive NH(2)-terminal part of its prohormone (NT-pro-BNP), in response to different kinds of myocardial stress. Hypoglycemia and hypoxemia are conditions that threaten cellular function and hence potentially stimulate BNP release. BNP interacts with the renin-angiotensin system (RAS). The aim of this study was, therefore, to explore if basal RAS activity has an impact on NT-pro-BNP concentrations during myocardial stress induced by hypoglycemia and hypoxemia. From a cohort of 303 healthy young men, 10 subjects with high-RAS activity and 10 subjects with low-RAS activity (age 26 +/- 1 yr; mean +/- SE) were studied in a single-blinded, randomized, counterbalanced, crossover study on three occasions separated by at least 3 wk: 1) hypoglycemia (mean nadir plasma glucose 2.7 +/- 0.5 mmol/l), 2) hypoxemia (mean nadir Po(2) 5.8 +/- 0.5 kPa), and 3) normoglycemic normoxia (control). NT-pro-BNP was measured at baseline, during the stimuli, and in the recovery phase. Hypoxemia was associated with a 9% increase in NT-pro-BNP from 2.2 +/- 1.5 pmol/l at baseline to 2.4 +/- 1.5 pmol/l during hypoxemia (P < 0.001). Hypoglycemia did not affect the NT-pro-BNP level. RAS activity had no impact on NT-pro-BNP levels during hypoglycemia and hypoxemia. Hypoxemia, but not hypoglycemia, stimulates NT-pro-BNP. This indicates that cardiac defense mechanisms against hypoglycemia, if any, are probably different from those against hypoxemia. Basal RAS activity had no impact on NT-pro-BNP levels.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Natriuretic Peptide, Brain,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Renin,
http://linkedlifedata.com/resource/pubmed/chemical/pro-brain natriuretic peptide (1-76)
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
8750-7587
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1080-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18258801-Adult,
pubmed-meshheading:18258801-Angiotensin II,
pubmed-meshheading:18258801-Anoxia,
pubmed-meshheading:18258801-Blood Glucose,
pubmed-meshheading:18258801-Blood Pressure,
pubmed-meshheading:18258801-Cross-Over Studies,
pubmed-meshheading:18258801-Humans,
pubmed-meshheading:18258801-Hypoglycemia,
pubmed-meshheading:18258801-Hypoglycemic Agents,
pubmed-meshheading:18258801-Insulin,
pubmed-meshheading:18258801-Male,
pubmed-meshheading:18258801-Natriuretic Peptide, Brain,
pubmed-meshheading:18258801-Peptide Fragments,
pubmed-meshheading:18258801-Reference Values,
pubmed-meshheading:18258801-Renin,
pubmed-meshheading:18258801-Renin-Angiotensin System
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pubmed:year |
2008
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pubmed:articleTitle |
NT-pro-BNP during hypoglycemia and hypoxemia in normal subjects: impact of renin-angiotensin system activity.
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pubmed:affiliation |
Endocrinology Section, Division of Internal Medicine I, Hillerød Hospital, Helsevej 2, DK-3400 Hillerød, Denmark. rsa@noh.regionh.dk
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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